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Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway
Wei, X.1; Tang, Z.1; Wu, H.1; Zuo, X.1; Dong, H.1; Tan, L.2; Wang, W.3; Liu, Y.1; Wu, Z.1; Shi, L.1; Wang, N.1; Li, X.4; Xiao, X.1; Guo, Z.4
Corresponding AuthorLi, X.(lxkfmmu@163.com) ; Xiao, X.(xiao_xxtyfsxx@sina.com) ; Guo, Z.(guozheng@fmmu.edu.cn)
2021-09-01
Source PublicationMATERIALS TODAY BIO
ISSN2590-0064
Volume12Pages:13
AbstractThe recurrence of osteosarcoma (OS) after reconstruction using Ti6Al4V prostheses remains a major problem in the surgical treatment of OS. Modification of the surfaces of Ti6Al4V prostheses with antitumor functions is an important strategy for improving therapeutic outcomes. Magnesium (Mg) coating has been shown to be multi-functional: it exhibits osteogenic and angiogenic properties and the potential to inhibit OS. In this study, we determined the proper concentration of released Mg2+ with respect to OS inhibition and biosafety and evaluated the anti-OS effects of Mg-coated Ti6Al4V scaffolds. We found that the release of Mg2+ during short-term and long-term degradation could significantly inhibit the proliferation and migration of HOS and 143B cells. Increased cell apoptosis and excessive autophagy were also observed, and further evidence of AMPK/mTOR/ULK1 signaling pathway activation was obtained both in vitro and in vivo, which suggested that the biofunctional scaffolds induce OS inhibition. Our study demonstrates the ability of an Mg coating to inhibit OS and may contribute to the further application of Mg-coated Ti6Al4V prostheses.
KeywordMagnesium Coating Antitumour Autophagy Apoptosis
DOI10.1016/j.mtbio.2021.100147
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000709924900001
PublisherELSEVIER
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/167071
Collection中国科学院金属研究所
Corresponding AuthorLi, X.; Xiao, X.; Guo, Z.
Affiliation1.Fourth Mil Med Univ, Xijing Hosp, Dept Orthopaed, Xian 710032, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.Fourth Mil Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China
4.Fourth Mil Med Univ, Tangdu Hosp, Dept Orthopaed, Xian 710038, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Wei, X.,Tang, Z.,Wu, H.,et al. Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway[J]. MATERIALS TODAY BIO,2021,12:13.
APA Wei, X..,Tang, Z..,Wu, H..,Zuo, X..,Dong, H..,...&Guo, Z..(2021).Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway.MATERIALS TODAY BIO,12,13.
MLA Wei, X.,et al."Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK/mTOR/ULK1 signaling pathway".MATERIALS TODAY BIO 12(2021):13.
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