| Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys | |
| Ren, Ling1; Xu, Xiaohe2; Liu, Hui1,3; Yang, Ke1; Qi, Xun4 | |
| Corresponding Author | Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com) |
| 2021-12-30 | |
| Source Publication | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| ISSN | 1005-0302 |
| Volume | 95Pages:237-248 |
| Abstract | To reduce the risk of implant-associated infections, we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role. However, both excessive and deficient Cu levels adversely affect human health; therefore, the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo . Moreover, the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated. The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate. The release rate maintained at a parts per billion level safe for humans; consequently, we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals. |
| Keyword | Cu ions Kinetic Biocompatibility Titanium |
| Funding Organization | National Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Startup Fundation for Docotors of Liaoning Province |
| DOI | 10.1016/j.jmst.2021.03.074 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC110060 0] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; National Natural Science Foundation[81873918] ; Startup Fundation for Docotors of Liaoning Province[2019BS-293] |
| WOS Research Area | Materials Science ; Metallurgy & Metallurgical Engineering |
| WOS Subject | Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering |
| WOS ID | WOS:000733964500002 |
| Publisher | JOURNAL MATER SCI TECHNOL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/167247 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Yang, Ke; Qi, Xun |
| Affiliation | 1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China 4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Peoples R China |
| Recommended Citation GB/T 7714 | Ren, Ling,Xu, Xiaohe,Liu, Hui,et al. Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,95:237-248. |
| APA | Ren, Ling,Xu, Xiaohe,Liu, Hui,Yang, Ke,&Qi, Xun.(2021).Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,95,237-248. |
| MLA | Ren, Ling,et al."Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 95(2021):237-248. |
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