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Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys
Ren, Ling1; Xu, Xiaohe2; Liu, Hui1,3; Yang, Ke1; Qi, Xun4
Corresponding AuthorYang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com)
2021-12-30
Source PublicationJOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
Volume95Pages:237-248
AbstractTo reduce the risk of implant-associated infections, we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role. However, both excessive and deficient Cu levels adversely affect human health; therefore, the aim of the present study was to comprehensively evaluate the short-and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo . Moreover, the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated. The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate. The release rate maintained at a parts per billion level safe for humans; consequently, we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility. (c) 2021 Published by Elsevier Ltd on behalf of Chinese Society for Metals.
KeywordCu ions Kinetic Biocompatibility Titanium
Funding OrganizationNational Key Research and Development Program of China ; LiaoNing Revitalization Talents Program ; National Natural Science Foundation ; Startup Fundation for Docotors of Liaoning Province
DOI10.1016/j.jmst.2021.03.074
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC110060 0] ; LiaoNing Revitalization Talents Program[XLYC1807069] ; National Natural Science Foundation[51631009] ; National Natural Science Foundation[31870954] ; National Natural Science Foundation[81873918] ; Startup Fundation for Docotors of Liaoning Province[2019BS-293]
WOS Research AreaMaterials Science ; Metallurgy & Metallurgical Engineering
WOS SubjectMaterials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS IDWOS:000733964500002
PublisherJOURNAL MATER SCI TECHNOL
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/167247
Collection中国科学院金属研究所
Corresponding AuthorYang, Ke; Qi, Xun
Affiliation1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China
2.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China
3.Univ Sci & Technol China, Sch Mat Sci & Engn, 96 Jinzhai Rd, Hefei 230026, Peoples R China
4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Peoples R China
Recommended Citation
GB/T 7714
Ren, Ling,Xu, Xiaohe,Liu, Hui,et al. Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,95:237-248.
APA Ren, Ling,Xu, Xiaohe,Liu, Hui,Yang, Ke,&Qi, Xun.(2021).Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,95,237-248.
MLA Ren, Ling,et al."Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 95(2021):237-248.
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