| Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing | |
| Yin, Jiewei1; Xu, Pengcheng2; Wu, Kang1; Zhou, Huan3; Lin, Xiao1; Tan, Lili4; Yang, Huilin2; Yang, Ke4; Yang, Lei1,3 | |
| Corresponding Author | Lin, Xiao(xlin@suda.edu.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Yang, Lei(ylei@hebut.edu.cn) |
| 2021-11-18 | |
| Source Publication | ACTA METALLURGICA SINICA-ENGLISH LETTERS
 |
| ISSN | 1006-7191 |
| Pages | 14 |
| Abstract | Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable problem. In this study, new macroporous and antibacterial gelatin/alginate (SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel matrix. The addition of Mg-Cu particles decreased the storage modulus of SAG, maintained its mechanical resilience and enhanced its water-absorbing capability. Moreover, the water vapor transmission rate of SAG added with 2 wt.% Mg-Cu (SAG-2MC) was 124% of that of medical gauze and 804% of commercial Tegaderm (TM) film dressing. The bacterial inhibition rates of SAG-2MC against S. aureus, E. coli and P. aeruginosa reached 99.9% +/- 0.1%, 98.7% +/- 1.2% and 98.0% +/- 0.7%, respectively, significantly greater than those of the SAG hydrogel and Mg particle-modified hydrogels. In addition, SAG-2MC hydrogel was biocompatible and promoted cell migration. In vivo experiment results indicated that SAG-2MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness, more collagen deposition and enhanced angiogenesis compared with SAG-0MC, SAG-2M and Tegaderm (TM) film. In summary, Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG hydrogels. Mg-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions. |
| Keyword | Mg-Cu alloy Wound repair Macroporous Hydrogel Bacterial inhibition |
| Funding Organization | National Natural Science Foundation of China ; National Key Research and Development Program of China ; Suzhou Science and Technology Project ; China Postdoctoral Science Foundation ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) |
| DOI | 10.1007/s40195-021-01335-w |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[82025025] ; National Natural Science Foundation of China[51672184] ; National Natural Science Foundation of China[31801585] ; National Natural Science Foundation of China[81622032] ; National Natural Science Foundation of China[32171321] ; National Key Research and Development Program of China[2020YFC1107401] ; Suzhou Science and Technology Project[SYS2019022] ; China Postdoctoral Science Foundation[2020T130459] ; Priority Academic Program Development of Jiangsu High Education Institutions (PAPD) |
| WOS Research Area | Metallurgy & Metallurgical Engineering |
| WOS Subject | Metallurgy & Metallurgical Engineering |
| WOS ID | WOS:000720204500001 |
| Publisher | CHINESE ACAD SCIENCES, INST METAL RESEARCH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/167485 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Lin, Xiao; Yang, Ke; Yang, Lei |
| Affiliation | 1.Soochow Univ, Coll Chem Chem Engn & Mat Sci, Orthoped Inst, Suzhou 215006, Peoples R China 2.Soochow Univ, Affiliated Hosp 1, Dept Orthopaed, Suzhou 215006, Peoples R China 3.Hebei Univ Technol, Ctr Hlth Sci & Engn CHSE, Sch Hlth Sci & Biomed Engn, Tianjin 300130, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Yin, Jiewei,Xu, Pengcheng,Wu, Kang,et al. Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2021:14. |
| APA | Yin, Jiewei.,Xu, Pengcheng.,Wu, Kang.,Zhou, Huan.,Lin, Xiao.,...&Yang, Lei.(2021).Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing.ACTA METALLURGICA SINICA-ENGLISH LETTERS,14. |
| MLA | Yin, Jiewei,et al."Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2021):14. |
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