| Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats | |
| Zhang, Xiyue1; Liu, Hui1; Li, Ling2; Huang, Cuishan2; Meng, Xiangbo2; Liu, Junzuo2; Bai, Xueling2; Ren, Ling1; Wang, Xinluan2,3; Yang, Ke1; Qin, Ling2,3 | |
| Corresponding Author | Ren, Ling(lren@imr.ac.cn) ; Wang, Xinluan(xl.wang@siat.ac.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Qin, Ling(lingqin@cuhk.edu.hk) |
| 2022-04-08 | |
| Source Publication | REGENERATIVE BIOMATERIALS
 |
| ISSN | 2056-3418 |
| Volume | 9Pages:13 |
| Abstract | Osteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture. However, the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to loosening. Thus, a new class of Cu-alloyed titanium (TiCu) alloys with excellent mechanical properties and bio-functionalization has been developed. In this study, the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of TiCu. The results showed that after implantation for 4 weeks, TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor expression. After 8 weeks, it could further promote the proliferation and differentiation of osteoblasts, mineralization and deposition of collagens, and then significantly increasing bone mineral density around the implant. In conclusion, TiCu alloy would enhance the fixation stability, accelerate the osteointegration, and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis environment. This study was the first to report the role and mechanism of a Cu-alloyed metal in promoting osteointegration in osteoporosis environment, which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys. |
| Keyword | copper-alloyed titanium alloy osteoporosis implant osseointegration vascularization |
| Funding Organization | Key Program for Foreign Cooperation of Chinese Academy of Sciences ; National Natural Science Foundation of China ; International Cooperation Program of Shenzhen Science and Technology Innovation Commission |
| DOI | 10.1093/rb/rbac011 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Key Program for Foreign Cooperation of Chinese Academy of Sciences[174321KYSB20180006] ; National Natural Science Foundation of China[51631009] ; International Cooperation Program of Shenzhen Science and Technology Innovation Commission[GJHZ20190821160803823] |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| WOS ID | WOS:000787385300003 |
| Publisher | OXFORD UNIV PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/172621 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Ren, Ling; Wang, Xinluan; Yang, Ke; Qin, Ling |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Translat Med Res Ctr, Shenzhen, Peoples R China 3.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaedis & Traumatol, Hong Kong, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China 5.Univ Sci & Technol China, Sch Mat Sci & Engn, 72 Wenhua Rd, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Xiyue,Liu, Hui,Li, Ling,et al. Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats[J]. REGENERATIVE BIOMATERIALS,2022,9:13. |
| APA | Zhang, Xiyue.,Liu, Hui.,Li, Ling.,Huang, Cuishan.,Meng, Xiangbo.,...&Qin, Ling.(2022).Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats.REGENERATIVE BIOMATERIALS,9,13. |
| MLA | Zhang, Xiyue,et al."Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats".REGENERATIVE BIOMATERIALS 9(2022):13. |
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