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Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats
Zhang, Xiyue1; Liu, Hui1; Li, Ling2; Huang, Cuishan2; Meng, Xiangbo2; Liu, Junzuo2; Bai, Xueling2; Ren, Ling1; Wang, Xinluan2,3; Yang, Ke1; Qin, Ling2,3
Corresponding AuthorRen, Ling(lren@imr.ac.cn) ; Wang, Xinluan(xl.wang@siat.ac.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Qin, Ling(lingqin@cuhk.edu.hk)
2022-04-08
Source PublicationREGENERATIVE BIOMATERIALS
ISSN2056-3418
Volume9Pages:13
AbstractOsteoporosis is a common skeletal disease making patients be prone to the osteoporotic fracture. However, the clinical implants made of titanium and its alloys with a poor osseointegration need a long time for healing and easily to loosening. Thus, a new class of Cu-alloyed titanium (TiCu) alloys with excellent mechanical properties and bio-functionalization has been developed. In this study, the osteoporosis modeled rats were used to study the osteointegration effect and underlying mechanism of TiCu. The results showed that after implantation for 4 weeks, TiCu alloy could promote the reconstruction of vascular network around the implant by up-regulating vascular endothelial growth factor expression. After 8 weeks, it could further promote the proliferation and differentiation of osteoblasts, mineralization and deposition of collagens, and then significantly increasing bone mineral density around the implant. In conclusion, TiCu alloy would enhance the fixation stability, accelerate the osteointegration, and thus reduce the risk of aseptic loosening during the long-term implantation in the osteoporosis environment. This study was the first to report the role and mechanism of a Cu-alloyed metal in promoting osteointegration in osteoporosis environment, which provides a new attractive support for the improvement of future clinical applications of Cu-alloyed antibacterial titanium alloys.
Keywordcopper-alloyed titanium alloy osteoporosis implant osseointegration vascularization
Funding OrganizationKey Program for Foreign Cooperation of Chinese Academy of Sciences ; National Natural Science Foundation of China ; International Cooperation Program of Shenzhen Science and Technology Innovation Commission
DOI10.1093/rb/rbac011
Indexed BySCI
Language英语
Funding ProjectKey Program for Foreign Cooperation of Chinese Academy of Sciences[174321KYSB20180006] ; National Natural Science Foundation of China[51631009] ; International Cooperation Program of Shenzhen Science and Technology Innovation Commission[GJHZ20190821160803823]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000787385300003
PublisherOXFORD UNIV PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/172621
Collection中国科学院金属研究所
Corresponding AuthorRen, Ling; Wang, Xinluan; Yang, Ke; Qin, Ling
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Translat Med Res Ctr, Shenzhen, Peoples R China
3.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Dept Orthopaedis & Traumatol, Hong Kong, Peoples R China
4.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China
5.Univ Sci & Technol China, Sch Mat Sci & Engn, 72 Wenhua Rd, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiyue,Liu, Hui,Li, Ling,et al. Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats[J]. REGENERATIVE BIOMATERIALS,2022,9:13.
APA Zhang, Xiyue.,Liu, Hui.,Li, Ling.,Huang, Cuishan.,Meng, Xiangbo.,...&Qin, Ling.(2022).Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats.REGENERATIVE BIOMATERIALS,9,13.
MLA Zhang, Xiyue,et al."Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats".REGENERATIVE BIOMATERIALS 9(2022):13.
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