Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo

doi:10.1016/j.jot.2022.02.008

IMR OpenIR

	Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo
	Guo, Yu 1,2; Chen, Chenglong 1,2; Zhang, Shuyuan 2; Ren, Ling 3; Zhao, Yanhui 3; Guo, Wei 1
通讯作者	Ren, Ling(lren@imr.ac.cn) ; Zhao, Yanhui(yhzhao@imr.ac.cn) ; Guo, Wei(bonetumor@163.com)
	2022-03-01
发表期刊	JOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN	2214-031X
卷号	33 页码:107-119
摘要	Background/Objective: TiCu/TiCuN is a multilayer composite coating comprising TiN and Cu, which provides excellent wear resistance and antibacterial properties. However, its applicability as a functional coating has not been widely realised, and several aspects pertaining to its properties must still be explored.Methods: This study uses arc ion-plating technology to apply a TiCu/TiCuN coating on the surface of carbon fibre reinforced (CFR) polyetheretherketone (PEEK) material.The safety and osteogenic activity of TiCu/TiCuN-coated CFR-PEEK materials were explored through cell experiments and animal experiments, and the molecules behind them were verified.Results: The new material exhibits improved mechanical compatibility (mechanical strength and elastic modulus) and superior light transmittance (elimination of metal artifacts and ray refraction during radiology and radiotherapy). The proposed implant delivers excellent biocompatibility for mesenchymal stem cells and human umbilical vein endothelial cells (HUVECs), and it exhibits excellent osteogenic activity both in vitro and in vivo. Additionally, it was determined that the applied TiCu/TiCuN coating aids in upregulating the expression of angiogenesis-related signals (i.e., cluster-of-differentiation 31, alpha-smooth muscle actin, vascular endothelial growth factor receptor, and hypoxia-inducible factor-1 alpha) to promote neovascularisation, which is significant for characterising the mechanism of the coating in promoting bone regeneration. Conclusion: The current results reveal that the TiCu/TiCuN-coated CFR-PEEK implants may emerge as an advanced generation of orthopaedic implants. Translational potential statement: The results of this study indicate that TiCu/TiCuN coating-modified CFR-PEEK materials can promote bone repair through angiogenesis and have broad clinical translation prospects.
关键词	Bone regeneration Carbon fibre -reinforced polyetheretherketone Orthopaedic implant TiCu TiCuN Vascularisation
资助者	Capital Health Development Scientific Research Special Project ; Beijing Science and Technology Planning Project ; National Natural Science Foundation of China
DOI	10.1016/j.jot.2022.02.008
收录类别	SCI
语种	英语
资助项目	Capital Health Development Scientific Research Special Project[2151000026] ; Beijing Science and Technology Planning Project[2144000054] ; National Natural Science Foundation of China[82072970]
WOS研究方向	Orthopedics
WOS类目	Orthopedics
WOS记录号	WOS:000783581400009
出版者	ELSEVIER
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/172879
专题	中国科学院金属研究所
通讯作者	Ren, Ling; Zhao, Yanhui; Guo, Wei
作者单位	1.Peking Univ Peoples Hosp, Musculoskeletal Tumor Ctr, 11 Xizhimen South St, Beijing 100044, Peoples R China 2.Beijing Key Lab Musculoskeletal Tumor, 11 Xizhimen South St, Beijing 100044, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Guo, Yu,Chen, Chenglong,Zhang, Shuyuan,et al. Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2022,33:107-119.
APA	Guo, Yu,Chen, Chenglong,Zhang, Shuyuan,Ren, Ling,Zhao, Yanhui,&Guo, Wei.(2022).Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo.JOURNAL OF ORTHOPAEDIC TRANSLATION,33,107-119.
MLA	Guo, Yu,et al."Mediation of mechanically adapted TiCu/TiCuN/CFR-PEEK implants in vascular regeneration to promote bone repair in vitro and in vivo".JOURNAL OF ORTHOPAEDIC TRANSLATION 33(2022):107-119.