Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br

doi:10.1021/acs.langmuir.2c00263

IMR OpenIR

	Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br
	Qian, Yifu 1,2; Zhao, Jing 3; Liu, Long 1; Hu, Hao 4; Wang, Bo 5; Zhang, Hongyu 2
通讯作者	Hu, Hao(huhao@bjmu.edu.cn) ; Wang, Bo(wb@sdust.edu.cn) ; Zhang, Hongyu(zhanghyu@tsinghua.edu.cn)
	2022-03-22
发表期刊	LANGMUIR
ISSN	0743-7463
卷号	38 期号:11 页码:3597-3606
摘要	Enhancing the lubrication property and bacterialresistance is extremely important for interventional biomedicalimplants to avoid soft tissue damage and biofilm formation. In this study, a zwitterionic phosphorylcholine coating (PMPC) was successfully developed to achieve surface functionalization of apolyurethane (PU)-based ureteral stent via subsurface"graftingfrom"photopolymerization. Typical surface characterizations suchas Fourier transform infrared spectroscopy, X-ray photoelectronspectroscopy, and surface wettability and morphology analysesexamined by scanning electron microscopy, atomic forcemicroscopy, and transmission electron microscopy demonstratedthat the phosphorylcholine polymer was grafted on the substratewith a thickness of 180 nm. Additionally, the tribological experiment performed by a universal material tester showed that thelubrication performance of PU-PMPC was significantly improved compared with that of PU. Thein vitroexperiments indicated thatthe PMPC coating was biocompatible and stably modified on the surface of the substrate with an excellent bacterial resistance rate of>90%. Furthermore, the result of thein vivoexperiment showed that the anti-encrustation performance of the surface-functionalizedureteral stent was better than that of the bare ureteral stent. The great enhancement in the lubrication, bacterial resistance, and anti-encrustation properties of the phosphorylcholine coating was thought to be due to the hydration effects of the zwitterionic charges. In summary, the bioinspired zwitterionic phosphorylcholine coating developed herein achieved significantly improved lubrication, bacterial resistance, and anti-encrustation performances and could be used as a convenient approach for surface functionalization of interventional biomedical implants
资助者	National Natural Science Foundation of China ; Capital's Funds for Health Improvement and Research, China ; Precision Medicine Foundation, Tsinghua University, China ; Liaoning Science and Technology Program ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China
DOI	10.1021/acs.langmuir.2c00263
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52022043] ; Capital's Funds for Health Improvement and Research, China[2020-2Z-40810] ; Precision Medicine Foundation, Tsinghua University, China[10001020120] ; Liaoning Science and Technology Program[2020JH2/10300159] ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China[SKLT2022C18]
WOS研究方向	Chemistry ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS记录号	WOS:000778529600027
出版者	AMER CHEMICAL SOC
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/172964
专题	中国科学院金属研究所
通讯作者	Hu, Hao; Wang, Bo; Zhang, Hongyu
作者单位	1.Hainan Univ, Sch Chem Engn & Technol, Haikou 570228, Hainan, Peoples R China 2.Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Peking Univ Peoples Hosp, Dept Urol, Beijing 100044, Peoples R China 5.Shandong Univ Sci & Technol, Sch Chem & Biol Engn, Qingdao 266590, Peoples R China
推荐引用方式 GB/T 7714	Qian, Yifu,Zhao, Jing,Liu, Long,et al. Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br[J]. LANGMUIR,2022,38(11):3597-3606.
APA	Qian, Yifu,Zhao, Jing,Liu, Long,Hu, Hao,Wang, Bo,&Zhang, Hongyu.(2022).Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br.LANGMUIR,38(11),3597-3606.
MLA	Qian, Yifu,et al."Bioinspired Phosphorylcholine Coating for Surface Functionalization of Interventional Biomedical Implants with Bacterial Resistance and Anti-Encrustation Properties br".LANGMUIR 38.11(2022):3597-3606.