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Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo
Gu, Guisong1,2; Erisen, Deniz Eren1,3; Yang, Ke1; Zhang, Bingchun1; Shen, Minggang2; Zou, Jingyu4; Qi, Xun5; Chen, Shanshan1; Xu, Xiaohe6
Corresponding AuthorChen, Shanshan(sschen@imr.ac.cn) ; Xu, Xiaohe(32626292@qq.com)
2022-03-07
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
ISSN1552-4973
Pages12
AbstractCopper ions (Cu) grafted chitosan coating was prepared using the pneumatic spraying method on the silicone rubber surface. Coating's surface properties, morphology, composition, Cu releasing behavior, antibacterial, and anti-inflammatory activities are investigated and discussed. Surface properties, composition, and morphology were investigated by scanning electron microscopy (SEM) and contact angle measurements. The antibacterial activity has been tested with Escherichia coli and Staphylococcus aureus suspensions in vitro. Besides, the morphology of the biofilm was inspected with a field emission SEM. To evaluate the anti-inflammatory activity and biosafety of the coating in vivo, the optimized coating samples and control groups were implanted subcutaneously into the back of mice. The bacterial environment model was established by injection of the bacterial suspension. The morphology and bacterial adhered on the surface of catheters and the surrounding tissues were analyzed after 5 days of implantation. As in vitro results, the number of adhered bacterial on the surface of the silicon rubber surface was decreased, and the anti-inflammatory rate was increased by the intensify of the Cu content in chitosan coating. As for in vivo results, after 5 days of implantation, there was no evident inflammation in the surrounding tissues of all catheters in all without the S. aureus injected group. In the injected chitosan/Cu coated group; the inflammation, the number of the adhered bacteria were observed less than other injected samples without Cu; no inflammation were noticeable. Results indicate that the Cu-modified chitosan coating can confer excellent antibacterial and anti-inflammatory activity as applied on medical catheters.
Keywordantibacterial catheter chitosan copper ion inflammation
Funding OrganizationDoctoral Start-up Foundation of Liaoning Province ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences
DOI10.1002/jbm.b.35047
Indexed BySCI
Language英语
Funding ProjectDoctoral Start-up Foundation of Liaoning Province[2019-BS-293] ; National Key Research and Development Program of China[2018YFC1105504] ; National Natural Science Foundation of China[51901227] ; National Natural Science Foundation of China[81701048] ; National Natural Science Foundation of China[81873918] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2019194]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000765366900001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/173241
Collection中国科学院金属研究所
Corresponding AuthorChen, Shanshan; Xu, Xiaohe
Affiliation1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
2.Univ Sci & Technol Liaoning, Sch Mat & Met, Anshan, Peoples R China
3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei, Anhui, Peoples R China
4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang, Peoples R China
5.China Med Univ, Dept Radiol, Affiliated Hosp 1, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Shenyang, Peoples R China
6.China Med Univ, Dept Ophthalmol, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Peoples R China
Recommended Citation
GB/T 7714
Gu, Guisong,Erisen, Deniz Eren,Yang, Ke,et al. Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2022:12.
APA Gu, Guisong.,Erisen, Deniz Eren.,Yang, Ke.,Zhang, Bingchun.,Shen, Minggang.,...&Xu, Xiaohe.(2022).Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,12.
MLA Gu, Guisong,et al."Antibacterial and anti-inflammatory activities of chitosan/copper complex coating on medical catheters: In vitro and in vivo".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2022):12.
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