| Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium | |
| Chen, Danhong1,2; Yu, Chengcheng1,2; Ying, Ying1,2; Luo, Yuanyi3; Ren, Ling4; Zhu, Caizhen3; Yang, Ke4; Wu, Buling1,2; Liu, Qi1,2 | |
| Corresponding Author | Wu, Buling(bulingwu@smu.edu.cn) ; Liu, Qi(liuqi0721@smu.edu.cn) |
| 2022-05-01 | |
| Source Publication | MOLECULES
 |
| Volume | 27Issue:10Pages:17 |
| Abstract | Peri-implantitis can lead to implant failure. In this study, curcumin (CUR) was modified onto the copper-bearing titanium alloy (Cu-Ti) with the assistance of polydopamine (PDA) in order to study the bone immune response and subsequent osteogenesis. FE-SEM, XPS and water contact angle were utilized to characterize the coating surface. Bone marrow mesenchymal stem cells (BMSCs) and macrophages were cultured separately and together onto the CUR modified Cu-Ti. Cell activity, expression of relative genes and proteins, cell migration ability, and fluorescence staining of cells were performed. CUR modification slightly increased the activation of M1-type and M2-type cells under physiological conditions. In the inflammation state, CUR inhibited the overexpression of M1 macrophages and induced M2-type differentiation. In addition, the modification itself could provoke the expression of osteoblastic-related genes of BMSCs, while promoting the osteogenic differentiation of BMSCs through the activation of macrophages in both physiological and inflammatory states. The BMSCs migration was increased, the expression of osteogenic-related genes and proteins was up-regulated, and alkaline phosphatase activity (ALP) was increased. Thus, the modification of CUR can promote the osteointegration effect of Cu-Ti by bone immunomodulation and may, in addition, improve the success rate of implants. |
| Keyword | curcumin copper-bearing titanium bone immunoregulation surface modification dental implant |
| Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Science and Technology Program Project of Guangzhou City ; College Students' Innovation and Entrepreneurship Training Program of Southern Medical University |
| DOI | 10.3390/molecules27103205 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[52003112] ; National Natural Science Foundation of China[81870755] ; National Natural Science Foundation of China[31870954] ; Natural Science Foundation of Guangdong Province[2018030310411] ; Science and Technology Program Project of Guangzhou City[202102080314] ; College Students' Innovation and Entrepreneurship Training Program of Southern Medical University[202012121009] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS ID | WOS:000802529200001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/174237 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Wu, Buling; Liu, Qi |
| Affiliation | 1.Southern Med Univ, Nanfang Hosp, Dept Stomatol, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China 2.Southern Med Univ, Coll Stomatol, 1838 North Guangzhou Ave, Guangzhou 510515, Peoples R China 3.Shenzhen Univ, Coll Chem & Environm Engn, Inst Low Dimens Mat Genome Initiat, Shenzhen 518060, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Danhong,Yu, Chengcheng,Ying, Ying,et al. Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium[J]. MOLECULES,2022,27(10):17. |
| APA | Chen, Danhong.,Yu, Chengcheng.,Ying, Ying.,Luo, Yuanyi.,Ren, Ling.,...&Liu, Qi.(2022).Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium.MOLECULES,27(10),17. |
| MLA | Chen, Danhong,et al."Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium".MOLECULES 27.10(2022):17. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment