Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites

doi:10.3389/fbioe.2022.913899

IMR OpenIR

	Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites
	Sun, Hui 1; Gao, Kefeng 2; Yi, Zhe 1; Han, Chengwei 3; Liu, Zengqian 2,4; Wang, Qiang 1; Zhou, Qing 1; Zhang, Zhefeng 2,4
通讯作者	Yi, Zhe(mfqwang@cmu.edu.cn) ; Wang, Qiang(zheyi@cmu.edu.cn)
	2022-05-23
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
ISSN	2296-4185
卷号	10 页码:12
摘要	For clinical applications, non-cytotoxicity and good bonding property of dental restorative materials are the most essential and important. The aim of this study was to evaluate the potential for clinical applications of two novel bioinspired nacre-like ceramic (yttria-stabilized zirconia)-polymer (polymethyl methacrylate) composites in terms of the cytotoxicity and bonding property. The relative growth rates (24 h) of the Lamellar and Brick-and-mortar composites measured by CCK8 were 102.93%+/- 0.04 and 98.91%+/- 0.03, respectively. According to the results of cytotoxicity and proliferation experiments, the two composites were not cytotoxic to human periodontal ligament fibroblasts (HPDLFs) in vitro. Both composites exhibited improved bonding strength as compared to the Control group (Vita In-Ceram YZ). As the polymer content in the composite material increases, its bonding strength also increases, which enhances the application potential of the material in the field of dental restoration. Meanwhile, by controlling the direction of loading force in the shear test, the effect of microstructure on the bonding strength of anisotropic composites was studied. After sandblasted, the bonding strengths of the Lamellar group in the longitudinal and transverse shear directions were 17.56 +/- 1.56 MPa and 18.67 +/- 1.92 MPa, respectively, while of the Brick-and-mortar group were 16.36 +/- 1.30 MPa and 16.99 +/- 1.67 MPa, respectively. The results showed that the loading direction had no significant effect on the bonding strength of the composites.
关键词	dental materials ceramic-polymer composite zirconia cytotoxicity bonding strength
资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Liaoning Revitalization Talents Program ; Youth Innovation Promotion Association CAS
DOI	10.3389/fbioe.2022.913899
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2020YFA0710404] ; National Natural Science Foundation of China[52173269] ; National Natural Science Foundation of China[51871216] ; Liaoning Revitalization Talents Program ; Youth Innovation Promotion Association CAS
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS记录号	WOS:000806850500001
出版者	FRONTIERS MEDIA SA
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/174285
专题	中国科学院金属研究所
通讯作者	Yi, Zhe; Wang, Qiang
作者单位	1.China Med Univ, Hosp Stomatol, Sch, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, Shenyang, Peoples R China 3.Liaoning Upcera Co Ltd, Benxi, Peoples R China 4.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Sun, Hui,Gao, Kefeng,Yi, Zhe,et al. Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:12.
APA	Sun, Hui.,Gao, Kefeng.,Yi, Zhe.,Han, Chengwei.,Liu, Zengqian.,...&Zhang, Zhefeng.(2022).Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10,12.
MLA	Sun, Hui,et al."Cytotoxicity and Bonding Property of Bioinspired Nacre-like Ceramic-Polymer Composites".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):12.