Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function

doi:10.1007/s40195-022-01435-1

IMR OpenIR

	Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function
	Yan, Yangyang 1,2; Li, Na 3; Guo, Feng 1,2; Wu, Anhua 4; Jin, Wei 1,2; Yang, Rui 1,2; Bai, Yun 1,2; Zhang, Xing 1,2
通讯作者	Bai, Yun(ybai@imr.ac.cn) ; Zhang, Xing(xingzhang@imr.ac.cn)
	2022-07-03
发表期刊	ACTA METALLURGICA SINICA-ENGLISH LETTERS
ISSN	1006-7191
页码	13
摘要	Intracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.
关键词	Nitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment
资助者	National Key Research and Development program
DOI	10.1007/s40195-022-01435-1
收录类别	SCI
语种	英语
资助项目	National Key Research and Development program[2018YFC1105503]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000820119600001
出版者	CHINESE ACAD SCIENCES, INST METAL RESEARCH
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/174887
专题	中国科学院金属研究所
通讯作者	Bai, Yun; Zhang, Xing
作者单位	1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China 4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yangyang,Li, Na,Guo, Feng,et al. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2022:13.
APA	Yan, Yangyang.,Li, Na.,Guo, Feng.,Wu, Anhua.,Jin, Wei.,...&Zhang, Xing.(2022).Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function.ACTA METALLURGICA SINICA-ENGLISH LETTERS,13.
MLA	Yan, Yangyang,et al."Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2022):13.