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Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function
Yan, Yangyang1,2; Li, Na3; Guo, Feng1,2; Wu, Anhua4; Jin, Wei1,2; Yang, Rui1,2; Bai, Yun1,2; Zhang, Xing1,2
Corresponding AuthorBai, Yun(ybai@imr.ac.cn) ; Zhang, Xing(xingzhang@imr.ac.cn)
2022-07-03
Source PublicationACTA METALLURGICA SINICA-ENGLISH LETTERS
ISSN1006-7191
Pages13
AbstractIntracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation.
KeywordNitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment
Funding OrganizationNational Key Research and Development program
DOI10.1007/s40195-022-01435-1
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development program[2018YFC1105503]
WOS Research AreaMetallurgy & Metallurgical Engineering
WOS SubjectMetallurgy & Metallurgical Engineering
WOS IDWOS:000820119600001
PublisherCHINESE ACAD SCIENCES, INST METAL RESEARCH
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/174887
Collection中国科学院金属研究所
Corresponding AuthorBai, Yun; Zhang, Xing
Affiliation1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China
3.Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China
4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China
Recommended Citation
GB/T 7714
Yan, Yangyang,Li, Na,Guo, Feng,et al. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2022:13.
APA Yan, Yangyang.,Li, Na.,Guo, Feng.,Wu, Anhua.,Jin, Wei.,...&Zhang, Xing.(2022).Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function.ACTA METALLURGICA SINICA-ENGLISH LETTERS,13.
MLA Yan, Yangyang,et al."Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2022):13.
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