| Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function | |
| Yan, Yangyang1,2; Li, Na3; Guo, Feng1,2; Wu, Anhua4; Jin, Wei1,2; Yang, Rui1,2; Bai, Yun1,2; Zhang, Xing1,2 | |
| Corresponding Author | Bai, Yun(ybai@imr.ac.cn) ; Zhang, Xing(xingzhang@imr.ac.cn) |
| 2022-07-03 | |
| Source Publication | ACTA METALLURGICA SINICA-ENGLISH LETTERS
 |
| ISSN | 1006-7191 |
| Pages | 13 |
| Abstract | Intracranial vascular stenting has been widely used for ischemic stroke. However, there are complication risks with stent implantation, such as poor wall apposition, stent migration, thromboembolism and stent restenosis, due to the mismatched radial force and conformability of the stents. Therefore, a novel intracranial vascular nitinol stent was fabricated in order to improve mechanical property and endothelialization function. The bending moment of the stents was calculated to be 0.346 N mm, which shows improved conformability. The radial force of the stents evaluated by the flat plate test was 0.0112 N/mm, within the range of the commercially available stent force (0.0065-0.0116 N/mm). Furthermore, the Tyr-Ile-Gly-Ser-Arg (YIGSR) peptide derived from laminin was grafted onto the stent surfaces to promote endothelialization on vascular stents evaluated by the proliferation, adhesion and migration of human umbilical vein endothelial cells in vitro. The nitinol stents with improved mechanical property and endothelialization function are expected to reduce the recurrence risk of ischemic stroke after implantation. |
| Keyword | Nitinol stents Conformability Radial force Endothelialization Intracranial stenosis treatment |
| Funding Organization | National Key Research and Development program |
| DOI | 10.1007/s40195-022-01435-1 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Research and Development program[2018YFC1105503] |
| WOS Research Area | Metallurgy & Metallurgical Engineering |
| WOS Subject | Metallurgy & Metallurgical Engineering |
| WOS ID | WOS:000820119600001 |
| Publisher | CHINESE ACAD SCIENCES, INST METAL RESEARCH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/174887 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Bai, Yun; Zhang, Xing |
| Affiliation | 1.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China 4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China |
| Recommended Citation GB/T 7714 | Yan, Yangyang,Li, Na,Guo, Feng,et al. Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2022:13. |
| APA | Yan, Yangyang.,Li, Na.,Guo, Feng.,Wu, Anhua.,Jin, Wei.,...&Zhang, Xing.(2022).Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function.ACTA METALLURGICA SINICA-ENGLISH LETTERS,13. |
| MLA | Yan, Yangyang,et al."Fabrication of Intracranial Vascular Nitinol Alloy Stents with Improved Mechanical Property and Endothelialization Function".ACTA METALLURGICA SINICA-ENGLISH LETTERS (2022):13. |
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