A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility

doi:10.3390/ma16020682

IMR OpenIR

	A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility
	Peng, Wenpeng 1,2,3; Chen, Yizhe 4; Fan, Hongde 4; Chen, Shanshan 5; Wang, Hui 4; Song, Xiang 1,2
通讯作者	Song, Xiang(song761231@sina.com)
	2023
发表期刊	MATERIALS
卷号	16 期号:2 页码:19
摘要	Problems of rapid degradation and poor biocompatibility (endothelialization and hemocompatibility) limit magnesium (Mg) alloy's further applications in vascular stents. To solve these problems, a novel composite coating was designed on Mg alloy via a two-step method. First, a Mg alloy sample was immersed in hydrofluoric acid. Then, a poly-l-lactic acid (PLLA) coating was made by ultrasonic atomization spraying with 5 and 10 layers (referred to as PLLA(5)-HF-Mg and PLLA(10)-HF-Mg). Characterizations were analyzed from the microstructure, element distribution, and wettability. The degradation behavior was tested with an electrochemical test and immersion test. Endothelialization was investigated using human umbilical vein endothelial cells (HUVECs). Hemocompatibility was examined with a platelet adhesion test. The results showed that the PLLA coating could not only cover the surface, but also could permeate through and cover the holes on the MgF2 layer, mechanically locked with the substrate. Thus, the composite coating had higher corrosion resistance. The PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, enhanced HUVECs' viability and growth. While incubated with platelets, the PLLA/MgF2 coating, especially on PLLA(10)-HF-Mg, had the lowest platelet adhesion number and activity. Taken together, the novel PLLA/MgF2 coating controls Mg alloy's degradation by spraying different layers of PLLA, resulting in better endothelialization and hemocompatibility, providing a promising candidate for cardiovascular stents.
关键词	biodegradable magnesium alloys poly-l-lactic acid hydrofluoric acid degradation biocompatibility
资助者	National Natural Science Foundation Council of China ; Young Elite Scientists Sponsorship Program by CAST ; China Postdoctoral Science Foundation
DOI	10.3390/ma16020682
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation Council of China[52175360] ; National Natural Science Foundation Council of China[51901227] ; Young Elite Scientists Sponsorship Program by CAST[2021QNRC001] ; China Postdoctoral Science Foundation[2022T150278] ; China Postdoctoral Science Foundation[2022M710062]
WOS研究方向	Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics
WOS类目	Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000916128700001
出版者	MDPI
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/175345
专题	中国科学院金属研究所
通讯作者	Song, Xiang
作者单位	1.Harbin Med Univ, Affiliated Hosp 4, Cardiovasc Ctr, Harbin 150000, Peoples R China 2.Harbin Med Univ, Dept Clin Med, Harbin 150000, Peoples R China 3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China 4.Wuhan Univ Technol, Hubei Key Lab Adv Technol Automot Components, Wuhan 430070, Peoples R China 5.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Peng, Wenpeng,Chen, Yizhe,Fan, Hongde,et al. A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility[J]. MATERIALS,2023,16(2):19.
APA	Peng, Wenpeng,Chen, Yizhe,Fan, Hongde,Chen, Shanshan,Wang, Hui,&Song, Xiang.(2023).A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility.MATERIALS,16(2),19.
MLA	Peng, Wenpeng,et al."A Novel PLLA/MgF2 Coating on Mg Alloy by Ultrasonic Atomization Spraying for Controlling Degradation and Improving Biocompatibility".MATERIALS 16.2(2023):19.