Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing

doi:10.1016/j.jma.2022.11.014

IMR OpenIR

	Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing
	Wang, Ning 1; Yang, Shude 1,2; Shi, Huixin 1; Song, Yiping 1; Sun, Hui 2; Wang, Qiang 2; Tan, Lili 3; Guo, Shu 1
通讯作者	Wang, Qiang(mfqwang@cmu.edu.cn) ; Tan, Lili(lltan@imr.ac.cn) ; Guo, Shu(sguo@cmu.edu.cn)
	2022-12-01
发表期刊	JOURNAL OF MAGNESIUM AND ALLOYS
ISSN	2213-9567
卷号	10 期号:12 页码:3327-3353
摘要	Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their superior mechanical properties, degradability, and excellent biocompatibility. Consistently, to resolve the issues on rapid degradation, more studies are dedicated to the researches on the composition design, preparation and processing, surface modification, the degradation modes of Mg alloys. Nevertheless, the mechanisms by which Mg alloys promote bone healing remain elusive. This review gives an account of specific mechanisms on Mg alloys promoting bone healing from four aspects, immunomodulatory, angiogenesis, osteogenesis and regulation of osteoclast function. We highlight the regulation of Mg alloys on the functional status and interactions of numerous cells that are involved in bone healing, including immune cells, osteogenic-related cells, osteoclasts, endothelial cells (ECs), nerve cells, etc., and summarize the signaling pathways involved, with the aim to provide the basis and support on future investigation on mechanisms on Mg alloys driving bone regeneration. More importantly, it provides a rationale and a general new basis for the application of Mg alloys in orthopedic fields. (c) 2022 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
关键词	Magnesium alloys Bone regeneration Immunomodulation Angiogenesis Osteogenesis
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; STS program ; DongGuan Innovative Research Team Program ; Natural Science Foundation of Liaoning Province ; China Postdoctoral Science Foundation
DOI	10.1016/j.jma.2022.11.014
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2020YFC1107501] ; National Natural Science Foundation of China[51971222] ; STS program[20201600200042] ; DongGuan Innovative Research Team Program ; Natural Science Foundation of Liaoning Province[2021-BS-103] ; China Postdoctoral Science Foundation[2020M681020]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000911252800003
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：54[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/175382
专题	中国科学院金属研究所
通讯作者	Wang, Qiang; Tan, Lili; Guo, Shu
作者单位	1.China Med Univ, Dept Plast Surg, Hosp 1, 115 Nanjing North St, Shenyang 110001, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, 117 Nanjing North St, Shenyang 110001, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ning,Yang, Shude,Shi, Huixin,et al. Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing[J]. JOURNAL OF MAGNESIUM AND ALLOYS,2022,10(12):3327-3353.
APA	Wang, Ning.,Yang, Shude.,Shi, Huixin.,Song, Yiping.,Sun, Hui.,...&Guo, Shu.(2022).Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing.JOURNAL OF MAGNESIUM AND ALLOYS,10(12),3327-3353.
MLA	Wang, Ning,et al."Magnesium alloys for orthopedic applications:A review on the mechanisms driving bone healing".JOURNAL OF MAGNESIUM AND ALLOYS 10.12(2022):3327-3353.