Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers

doi:10.1016/j.jmst.2022.09.063

IMR OpenIR

	Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers
	Guo, Feng 1,2; Han, Rizheng 1,2; Ying, Jishan 1,2; Zhang, Zeping 1,2; Yang, Rui 1,2; Zhang, Xing 1,2
通讯作者	Zhang, Xing(xingzhang@imr.ac.cn)
	2023-05-01
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	144 页码:178-187
摘要	In this work, bioinspired anisotropic polymeric heart valves were fabricated using composite materials from polyurethane (PU) and natural cellulose fiber bundles. Cellulose fibers with good alignment were obtained from balsa wood by a top-down process, which were then distributed in polyurethane to pre-pare cellulose fiber bundles reinforced polyurethane (CPU) by hot pressing. The storage modulus of the CPU along the direction parallel to the fiber alignment was 16.70 +/- 0.80 MPa, whereas that along the direction perpendicular to the fiber alignment was 8.41 +/- 0.94 MPa by dynamic mechanical analysis (DMA) tests at 1 Hz, comparable to aortic valve leaflets. Moreover, 2-methacryloyloxyethyl phosphoryl-choline (MPC) was grafted onto the CPU surface (CPU-MPC) to improve hemocompatibility. With MPC modification, the water contact angle decreased significantly from 54.58 degrees +/- 2.98 degrees to 26.42 degrees +/- 3.50 degrees, and the platelet adhesion was reduced by 92%, compared to the original CPU. In vitro cell culture proved that both CPU and CPU-MPC samples did not show any cytotoxicity. Furthermore, the CPU composites were used to fabricate polymeric heart valves, which showed excellent hydrodynamic performance with a large orifice area (1.70 cm2) and low regurgitation fraction (0.7%), meeting the requirements of ISO 5840-2 standard.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science &Technology.
关键词	Polymeric heart valve Anisotropy Cellulose fibers Polyurethane
资助者	National Key Re-search and Development Program ; National Natural Science Foundation of China
DOI	10.1016/j.jmst.2022.09.063
收录类别	SCI
语种	英语
资助项目	National Key Re-search and Development Program ; National Natural Science Foundation of China ; [2018YFC1105503] ; [31670981]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000901716800005
出版者	JOURNAL MATER SCI TECHNOL
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/175682
专题	中国科学院金属研究所
通讯作者	Zhang, Xing
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
推荐引用方式 GB/T 7714	Guo, Feng,Han, Rizheng,Ying, Jishan,et al. Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2023,144:178-187.
APA	Guo, Feng,Han, Rizheng,Ying, Jishan,Zhang, Zeping,Yang, Rui,&Zhang, Xing.(2023).Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,144,178-187.
MLA	Guo, Feng,et al."Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 144(2023):178-187.