| Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers | |
| Guo, Feng1,2; Han, Rizheng1,2; Ying, Jishan1,2; Zhang, Zeping1,2; Yang, Rui1,2; Zhang, Xing1,2 | |
| Corresponding Author | Zhang, Xing(xingzhang@imr.ac.cn) |
| 2023-05-01 | |
| Source Publication | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
 |
| ISSN | 1005-0302 |
| Volume | 144Pages:178-187 |
| Abstract | In this work, bioinspired anisotropic polymeric heart valves were fabricated using composite materials from polyurethane (PU) and natural cellulose fiber bundles. Cellulose fibers with good alignment were obtained from balsa wood by a top-down process, which were then distributed in polyurethane to pre-pare cellulose fiber bundles reinforced polyurethane (CPU) by hot pressing. The storage modulus of the CPU along the direction parallel to the fiber alignment was 16.70 +/- 0.80 MPa, whereas that along the direction perpendicular to the fiber alignment was 8.41 +/- 0.94 MPa by dynamic mechanical analysis (DMA) tests at 1 Hz, comparable to aortic valve leaflets. Moreover, 2-methacryloyloxyethyl phosphoryl-choline (MPC) was grafted onto the CPU surface (CPU-MPC) to improve hemocompatibility. With MPC modification, the water contact angle decreased significantly from 54.58 degrees +/- 2.98 degrees to 26.42 degrees +/- 3.50 degrees, and the platelet adhesion was reduced by 92%, compared to the original CPU. In vitro cell culture proved that both CPU and CPU-MPC samples did not show any cytotoxicity. Furthermore, the CPU composites were used to fabricate polymeric heart valves, which showed excellent hydrodynamic performance with a large orifice area (1.70 cm2) and low regurgitation fraction (0.7%), meeting the requirements of ISO 5840-2 standard.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science &Technology. |
| Keyword | Polymeric heart valve Anisotropy Cellulose fibers Polyurethane |
| Funding Organization | National Key Re-search and Development Program ; National Natural Science Foundation of China |
| DOI | 10.1016/j.jmst.2022.09.063 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Key Re-search and Development Program ; National Natural Science Foundation of China ; [2018YFC1105503] ; [31670981] |
| WOS Research Area | Materials Science ; Metallurgy & Metallurgical Engineering |
| WOS Subject | Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering |
| WOS ID | WOS:000901716800005 |
| Publisher | JOURNAL MATER SCI TECHNOL |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/175682 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhang, Xing |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China |
| Recommended Citation GB/T 7714 | Guo, Feng,Han, Rizheng,Ying, Jishan,et al. Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2023,144:178-187. |
| APA | Guo, Feng,Han, Rizheng,Ying, Jishan,Zhang, Zeping,Yang, Rui,&Zhang, Xing.(2023).Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,144,178-187. |
| MLA | Guo, Feng,et al."Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 144(2023):178-187. |
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