Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation

doi:10.1088/2053-1591/acad67

IMR OpenIR

	Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation
	Erisen, Deniz Eren 1,2; Gu, Guisong 2,3; Chen, Shanshan 2; Yang, Ke 2; Zhang, Bingchun 2; Shen, Minggang 3
通讯作者	Erisen, Deniz Eren(deniz17b@imr.ac.cn) ; Chen, Shanshan(sschen@imr.ac.cn)
	2022-12-01
发表期刊	MATERIALS RESEARCH EXPRESS
卷号	9 期号:12 页码:8
摘要	Background: Catheters are polymeric materials frequently used in clinics and are associated with the risk of inflammation and coagulation. The development of bioactive catheter surfaces is worth applying because antibiotic resistance in bacterial infections is common. Copper (Cu) ion coordinated chitosan (Chitosan-Cu) coatings on medical catheters, and several studies have recently approved its application. Objective: It is crucial to investigate the possible cytotoxicity of Chitosan-Cu coatings on surrounding cells. Methods: The effect of the Chitosan-Cu complex coating, proven to have bioactive activities at different rates on L929 cells, was examined by the CCK-8 test kit. In 24 h, the cell viabilities of samples, with Chitosan: Cu ratios of 10:0, 10:1, 50:1, and 100:1, were measured as 105.14%, 89.90%, 91.91%, and 100.75%, respectively. In 72 h, they were measured at 119.45%, 109.33%, 110.24%, and 114.45%. The surface morphology of the coating was characterized by electron microscopy, and the entity of the Cu ions in the coating was characterized by x-ray photoelectron spectroscopy. Conclusion: Cytotoxicity assays showed that Cu, with a maximum concentration of 10% by volume, showed no toxic behavior.
关键词	biomedical materials copper chitosan cytotoxicity
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; Doctoral StartupFund of Liaoning Province
DOI	10.1088/2053-1591/acad67
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China ; National Natural Science Foundation of China[2018YFC1105504] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[51901227] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[81701048] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[81873918] ; Doctoral StartupFund of Liaoning Province[2019194] ; [2019-BS-293]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000905814600001
出版者	IOP Publishing Ltd
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/175720
专题	中国科学院金属研究所
通讯作者	Erisen, Deniz Eren; Chen, Shanshan
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, Jinzhai Rd 96, CN-230026 Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 3.Univ Sci & Technol Liaoning, Sch Mat & Met, 189 Qianshan Middle Rd, Anshan 114051, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Erisen, Deniz Eren,Gu, Guisong,Chen, Shanshan,et al. Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation[J]. MATERIALS RESEARCH EXPRESS,2022,9(12):8.
APA	Erisen, Deniz Eren,Gu, Guisong,Chen, Shanshan,Yang, Ke,Zhang, Bingchun,&Shen, Minggang.(2022).Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation.MATERIALS RESEARCH EXPRESS,9(12),8.
MLA	Erisen, Deniz Eren,et al."Synthesis of chitosan-Cu based bioactive material for coating catheters: in vitro cytotoxicity evaluation".MATERIALS RESEARCH EXPRESS 9.12(2022):8.