Modulation of Osteogenesis and Angiogenesis Activities Based on Ionic Release from Zn-Mg Alloys

doi:10.3390/ma15207117

IMR OpenIR

	Modulation of Osteogenesis and Angiogenesis Activities Based on Ionic Release from Zn-Mg Alloys
	Wang, Ziming 1; Wang, Weidan 1,2; Zhang, Xiuzhi 1; Cao, Fang 1,3; Zhang, Tianwei 1,4; Pokharel, Durga Bhakta 1,2; Chen, Di 1; Li, Junlei 1; Yang, Jiahui 1; Xiao, Chi 1; Ren, Yuping 5; Qin, Gaowu 5; Zhao, Dewei 1
通讯作者	Zhang, Xiuzhi(dr_zhangxiuzhi@163.com) ; Zhao, Dewei(zhaodewei2000@163.com)
	2022-10-01
发表期刊	MATERIALS
卷号	15 期号:20 页码:18
摘要	The enhancement of osteogenesis and angiogenesis remains a great challenge for the successful regeneration of engineered tissue. Biodegradable Mg and Zn alloys have received increasing interest as potential biodegradable metallic materials, partially due to the biological functions of Mg2+ and Zn2+ with regard to osteogenesis and angiogenesis, respectively. In the present study, novel biodegradable Zn-xMg (x = 0.2, 0.5, 1.0 wt.%) alloys were designed and fabricated, and the effects of adding different amounts of Mg to the Zn matrix were investigated. The osteogenesis and angiogenesis beneficial effects of Zn2+ and Mg2+ release during the biodegradation were characterized, demonstrating coordination with the bone regeneration process in a dose-dependent manner. The results show that increased Mg content leads to a higher amount of released Mg2+ while decreasing the Zn2+ concentration in the extract. The osteogenesis of pre-osteoblasts was promoted in Zn-0.5Mg and Zn-1Mg due to the higher concentration of Mg2+. Moreover, pure Zn extract presented the highest activity in angiogenesis, owing to the highest concentration of Zn2+ release (6.415 mu g/mL); the proliferation of osteoblast cells was, however, inhibited under such a high Zn2+ concentration. Although the concentration of Zn ion was decreased in Zn-0.5Mg and Zn-1Mg compared with pure Zn, the angiogenesis was not influenced when the concentration of Mg in the extract was sufficiently increased. Hence, Mg2+ and Zn2+ in Zn-Mg alloys show a dual modulation effect. The Zn-0.5Mg alloy was indicated to be a promising implant candidate due to demonstrating the appropriate activity in regulating osteogenesis and angiogenesis. The present work evaluates the effect of the Mg content in Zn-based alloys on biological activities, and the results provide guidance regarding the Zn-Mg composition in designs for orthopedic application.
关键词	bone regeneration microenvironment Mg ion synergistic effect Zn ion
资助者	Dalian Key Medical Specialties Peak Climbing Program ; National Orthopedic and Sports Rehabilitation ClinicalMedical Research Center Innovation Fund ; KeyR&DProgramof Liaoning Province ; Scientific Study Project ofMinistry of Education, Liaoning Province
DOI	10.3390/ma15207117
收录类别	SCI
语种	英语
资助项目	Dalian Key Medical Specialties Peak Climbing Program[2021(243)] ; National Orthopedic and Sports Rehabilitation ClinicalMedical Research Center Innovation Fund[2021-NCRC-CXJJ-ZH-28] ; KeyR&DProgramof Liaoning Province[2020JH2/10300093] ; Scientific Study Project ofMinistry of Education, Liaoning Province[LJKQZ2021169]
WOS研究方向	Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics
WOS类目	Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000873262100001
出版者	MDPI
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/176389
专题	中国科学院金属研究所
通讯作者	Zhang, Xiuzhi; Zhao, Dewei
作者单位	1.Dalian Univ, Dept Orthopaed, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Dalian Univ Technol, Dept Biomed Engn, Dalian 116024, Peoples R China 4.Dalian Jiaotong Univ, Sch Mech Engn, Dalian 116028, Peoples R China 5.Northeastern Univ, Sch Mat Sci & Engn, Shenyang 110819, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ziming,Wang, Weidan,Zhang, Xiuzhi,et al. Modulation of Osteogenesis and Angiogenesis Activities Based on Ionic Release from Zn-Mg Alloys[J]. MATERIALS,2022,15(20):18.
APA	Wang, Ziming.,Wang, Weidan.,Zhang, Xiuzhi.,Cao, Fang.,Zhang, Tianwei.,...&Zhao, Dewei.(2022).Modulation of Osteogenesis and Angiogenesis Activities Based on Ionic Release from Zn-Mg Alloys.MATERIALS,15(20),18.
MLA	Wang, Ziming,et al."Modulation of Osteogenesis and Angiogenesis Activities Based on Ionic Release from Zn-Mg Alloys".MATERIALS 15.20(2022):18.