High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application

doi:10.1002/srin.202200355

IMR OpenIR

	High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application
	Chen, Shanshan 1; Wang, Qingchuan 1; Yang, Hui 2; Yang, Ke 1
通讯作者	Yang, Ke(kyang@imr.ac.cn)
	2022-11-28
发表期刊	STEEL RESEARCH INTERNATIONAL
ISSN	1611-3683
页码	11
摘要	Metal materials such as stainless steel, cobalt-based alloy, and NiTi alloy used in clinic contain a certain amount of nickel (Ni) for the structure stability. Nickel ions can gradually dissolve into the human body even with much slow corrosion rate, causing allergic, inflammation, local tissue proliferation, and other adverse reactions to some people. To avoid these adverse effects of nickel, a new high-nitrogen nickel-free stainless steel (HNNFSS) using nitrogen and manganese instead of nickel to stabilize the austenite structure is developed, which exhibits much better mechanical properties, good corrosion resistance, and biocompatibility. Compared with the conventional orthopedic metal implants, the adhesion strength of HNNFSS implant with the surrounding tissue in animal is found to be stronger with new bone formation, promoted by both alkaline phosphatase (ALP) and osteocalcin (OCN) expressions. The vascular stent made of HNNFSS shows lower restenosis rate compared with the traditional 316L stainless steel stent, which is attributed to the promotion of endothelial cell and inhibition of smooth muscle cells, and superior blood compatibility. In conclusion, results from large number of studies show that high-nitrogen nickel-free stainless steel as a new kind of high-performance biomedical metallic material possesses great application potential.
关键词	biocompatibility bone implants coronary stents corrosion resistances high-nitrogen nickel-free stainless steels mechanical properties
资助者	Youth Innovation Promotion Association, Chinese Academy of Sciences
DOI	10.1002/srin.202200355
收录类别	SCI
语种	英语
资助项目	Youth Innovation Promotion Association, Chinese Academy of Sciences ; [2019194]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:000890423700001
出版者	WILEY-V C H VERLAG GMBH
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/176986
专题	中国科学院金属研究所
通讯作者	Yang, Ke
作者单位	1.Chinese Acad Sci, Inst Met Res, Shi changxu Innovat Ctr Adv Mat, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Zhongke Yian Med Technol Beijing Co Ltd, 2 Xiang St, Zone B, Airport Dev Tone, Beijing 101318, Peoples R China
推荐引用方式 GB/T 7714	Chen, Shanshan,Wang, Qingchuan,Yang, Hui,et al. High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application[J]. STEEL RESEARCH INTERNATIONAL,2022:11.
APA	Chen, Shanshan,Wang, Qingchuan,Yang, Hui,&Yang, Ke.(2022).High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application.STEEL RESEARCH INTERNATIONAL,11.
MLA	Chen, Shanshan,et al."High-Nitrogen Nickel-Free Stainless Steel: An Attractive Material with Potential for Biomedical Application".STEEL RESEARCH INTERNATIONAL (2022):11.