| In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings | |
| Liu, Yuzhi1; Chen, Changtian2; Liang, Tao1; Wang, Yaping1,2; Zhao, Rongfang2; Li, Guoqiang2; Bai, Chunguang3; Wu, Yuxi4; Yu, Fanglei5; Sheng, Liyuan6; Zhang, Rongfa2; Zhao, Ying1 | |
| Corresponding Author | Bai, Chunguang(cgbai@imr.ac.cn) ; Zhang, Rongfa(rfzhang-10@163.com) ; Zhao, Ying(ying.zhao@siat.ac.cn) |
| 2024 | |
| Source Publication | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| ISSN | 0927-7765 |
| Volume | 233Pages:11 |
| Abstract | Micro-arc oxidation (MAO) coatings containing 2.86 wt%, 5.83 wt% and 8.81 wt% Zn (Zn-2.86 wt%, Zn-5.83 wt % and Zn-8.81 wt%) were separately fabricated on Ti6Al4V alloys using EDTA-ZnNa2 electrolytes. In vitro antibacterial examination exhibits that the antibacterial rates of Zn-2.86 wt%, Zn-5.83 wt% and Zn-8.81 wt% against Staphylococcus aureus (S. aureus) are 76.0 %, 100.0 % and 99.2 %, respectively. Reactive oxygen species (ROS) level of MAO samples is significantly higher than that of the untreated Ti6Al4V. Zn-containing coatings especially Zn-5.83 wt% induces the strongest oxidative stress on S. aureus due to relatively high released Zn2+ concentration. Moreover, qPCR analysis shows that MAO samples inhibit the icaADBC transcription and result in the down-regulation of PIA production, thereby mitigating biofilm formation. After immersion in simulated body fluid (SBF) for 3, 8 and 14 d, the antibacterial rate of Zn-5.83 wt% is 84.7 %, 63.2 % and 12.5 % respectively, and ROS level of MAO samples is also significantly higher than that of the untreated Ti6Al4V even after 14 d of immersion, suggesting that the antibacterial performance of MAO samples can last a relatively long immersion period and exhibit large application potential in orthopedic clinic. |
| Keyword | Titanium alloys Micro-arc oxidation Zn-doped coatings Antibacterial performance |
| Funding Organization | Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology) |
| DOI | 10.1016/j.colsurfb.2023.113634 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology)[JCYJ20210324120009026] ; Open Project Program of Anhui Province Key Laboratory of Metallurgical Engineering & Resources Recycling (Anhui University of Technology)[JCYJ20210324102013036] ; [SKF23-04] |
| WOS Research Area | Biophysics ; Chemistry ; Materials Science |
| WOS Subject | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| WOS ID | WOS:001112711300001 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/177250 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Bai, Chunguang; Zhang, Rongfa; Zhao, Ying |
| Affiliation | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 2.Jiangxi Sci & Technol Normal Univ, Sch Mat & Mech & Elect Engn, Nanchang 330013, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Anhui Univ Technol, Key Lab Met Emiss Reduct & Resources Recycling, Minist Educ, Maanshan 243002, Peoples R China 5.Zhejiang Canwell Med Co Ltd, Jinhua 321000, Peoples R China 6.Peking Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yuzhi,Chen, Changtian,Liang, Tao,et al. In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2024,233:11. |
| APA | Liu, Yuzhi.,Chen, Changtian.,Liang, Tao.,Wang, Yaping.,Zhao, Rongfang.,...&Zhao, Ying.(2024).In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings.COLLOIDS AND SURFACES B-BIOINTERFACES,233,11. |
| MLA | Liu, Yuzhi,et al."In vitro long-term antibacterial performance and mechanism of Zn-doped micro-arc oxidation coatings".COLLOIDS AND SURFACES B-BIOINTERFACES 233(2024):11. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment