Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization

doi:10.3389/fbioe.2023.1300336

IMR OpenIR

	Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization
	Bi, Shijun 1,2; Lin, Hao 3; Zhu, Kunyuan 1,4; Zhu, Zechao 1; Zhang, Wenxu 1; Yang, Xinyu 1; Chen, Shanshan 3; Zhao, Jing 3; Liu, Meixia 3; Pan, Pengyu 1; Liang, Guobiao 1
通讯作者	Pan, Pengyu(panpengyu09@sina.com) ; Liang, Guobiao(liangguobiao6708@163.com)
	2023-11-13
发表期刊	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
ISSN	2296-4185
卷号	11 页码:11
摘要	Introduction: Intracranial stents are of paramount importance in managing cerebrovascular disorders. Nevertheless, the currently employed drug-eluting stents, although effective in decreasing in-stent restenosis, might impede the re-endothelialization process within blood vessels, potentially leading to prolonged thrombosis development and restenosis over time.Methods: This study aims to construct a multifunctional bioactive coating to enhance the biocompatibility of the stents. Salvianolic acid B (SALB), a bioactive compound extracted from Salvia miltiorrhiza, exhibits potential for improving cardiovascular health. We utilized dopamine as the base and adhered chitosan-coated SALB microspheres onto nickel-titanium alloy flat plates, resulting in a multifunctional drug coating.Results: By encapsulating SALB within chitosan, the release period of SALB was effectively prolonged, as evidenced by the in vitro drug release curve showing sustained release over 28 days. The interaction between the drug coating and blood was examined through experiments on water contact angle, clotting time, and protein adsorption. Cellular experiments showed that the drug coating stimulates the proliferation, adhesion, and migration of human umbilical vein endothelial cells.Discussion: These findings indicate its potential to promote re-endothelialization. In addition, the bioactive coating effectively suppressed smooth muscle cells proliferation, adhesion, and migration, potentially reducing the occurrence of neointimal hyperplasia and restenosis. These findings emphasize the exceptional biocompatibility of the newly developed bioactive coating and demonstrate its potential clinical application as an innovative strategy to improve stent therapy efficacy. Thus, this coating holds great promise for the treatment of cerebrovascular disease.
关键词	cerebrovascular disease stent stenosis interventional therapy salvianolic acid B chitosan surface modification endothelialization restenosis
资助者	National Natural Science Foundation of China ; Liaoning Revitalization Talents Program ; Liaoning Key Research and Development Project ; Research Project of Shenyang Bureau of Science and Technology
DOI	10.3389/fbioe.2023.1300336
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81971133] ; National Natural Science Foundation of China[82071481] ; National Natural Science Foundation of China[82301487] ; Liaoning Revitalization Talents Program[XLYC2002109] ; Liaoning Key Research and Development Project[2021JH2/10300059] ; Research Project of Shenyang Bureau of Science and Technology[20-205-4-017]
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
WOS记录号	WOS:001107369500001
出版者	FRONTIERS MEDIA SA
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/177380
专题	中国科学院金属研究所
通讯作者	Pan, Pengyu; Liang, Guobiao
作者单位	1.Gen Hosp Northern Theater Command, Dept Neurosurg, Shenyang, Peoples R China 2.Dalian Med Univ, Grad Sch, Dalian, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 4.China Med Univ, Grad Sch, Shenyang, Peoples R China
推荐引用方式 GB/T 7714	Bi, Shijun,Lin, Hao,Zhu, Kunyuan,et al. Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2023,11:11.
APA	Bi, Shijun.,Lin, Hao.,Zhu, Kunyuan.,Zhu, Zechao.,Zhang, Wenxu.,...&Liang, Guobiao.(2023).Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,11,11.
MLA	Bi, Shijun,et al."Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11(2023):11.