| In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials | |
| Chang, Peng1; Guo, Kai2; Li, Shijie2; Wang, Hongtao3; Tang, Mingqiang3,4 | |
| 通讯作者 | Chang, Peng(cp17625@163.com) |
| 2023-11-07 | |
| 发表期刊 | SMALL
 |
| ISSN | 1613-6810 |
| 页码 | 13 |
| 摘要 | Current fish collagen hemostasis for wound healing products is commonly obtained by electrospinning or artificial cross-linking fish collagen fibers which lacks mechanical properties, and biofunctions. Here, a new bio-active fish skin scaffold (FSS) is shown using in situ cross-linked scaleless freshwater fish skin adding adipose-derived stem cells (ASCs)-produced exosomes for hemostasis and wound healing. The structure, pore size, and the thickness of FSS is studied by swelling test, Fourier-transform infrared (FT-IR) spectra, scanning electron microscope (SEM) images, and histological analysis. The biofunctions of the FSS are also tested in vitro and in vivo. FSS keeps two functional layers: The dermis layer collagen forms a sponge like structure after swelling and in situ cross-linking treatments. The pore size of the FSS is approximate to 152 +/- 23.54 mu m, which is suitable for cells growing, angiogenesis and ASCs exosomes accelerate wound healing. The fat-rich epidermis layer can keep the wound moisty and clean before completely healed. In vitro and in vivo experimental results indicate that FSS+Exosomes enhances rat skin cavity wound healing. In situ sodium chloride cross-linked FSS+Exosomes provides a new strategy as functional hemostatic dressing scaffold for wound healing. A new kind of functional hemostasis scaffold is derived from a kind of new scaleless freshwater fish (Cyprinus carpio var. specularis) skin (FSS). The FSS prepared from scaleless freshwater fish skin treated with acetic acid (HAc) and cross-linked with NaCl has suitable structure for exosome loading. The ASC-exosome-containing FSS has hemostatic effect and enhances rat skin cavity wound healing.image |
| 关键词 | adipose-derived stem cells exosomes fish skin scaffold hemostasis wound healing |
| 资助者 | This work was supported by the National Natural Science Foundation of China (no. 82372550); the Natural Science Foundation of Shenyang Science and Technology Bureau (no. 21-172-9-15); the Natural Science Foundation of Liaoning Province (no. 2022-YGJH-28); ; National Natural Science Foundation of China ; Natural Science Foundation of Shenyang Science and Technology Bureau ; Natural Science Foundation of Liaoning Province ; Shengjing Hospital 345 Talent Project ; Postdoctoral start-up fund of China Medical University |
| DOI | 10.1002/smll.202208001 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | This work was supported by the National Natural Science Foundation of China (no. 82372550); the Natural Science Foundation of Shenyang Science and Technology Bureau (no. 21-172-9-15); the Natural Science Foundation of Liaoning Province (no. 2022-YGJH-28);[82372550] ; National Natural Science Foundation of China[21-172-9-15] ; Natural Science Foundation of Shenyang Science and Technology Bureau[2022-YGJH-28] ; Natural Science Foundation of Liaoning Province[2023 40B] ; Shengjing Hospital 345 Talent Project[M0972] ; Postdoctoral start-up fund of China Medical University |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| WOS记录号 | WOS:001096209300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/177588 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Chang, Peng |
| 作者单位 | 1.China Med Univ, Shengjing Hosp, Dept Plast & Cosmet Surg, Shenyang 110004, Peoples R China 2.Chinese Acad Sci, Shenyang Inst Automat, Shenyang 110000, Liaoning, Peoples R China 3.Shenyang Elite Blue Med Technol EBG Co Ltd, Shenyang 110004, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Peng,Guo, Kai,Li, Shijie,et al. In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials[J]. SMALL,2023:13. |
| APA | Chang, Peng,Guo, Kai,Li, Shijie,Wang, Hongtao,&Tang, Mingqiang.(2023).In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials.SMALL,13. |
| MLA | Chang, Peng,et al."In Situ Sodium Chloride Cross-Linked Fish Skin Collagen Scaffolds for Functional Hemostasis Materials".SMALL (2023):13. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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