Enhanced Degradability of the Apatite-Based Calcium Phosphate Cement Incorporated with Amorphous MgZnCa Alloy

doi:10.1021/acsbiomaterials.3c00853

IMR OpenIR

	Enhanced Degradability of the Apatite-Based Calcium Phosphate Cement Incorporated with Amorphous MgZnCa Alloy
	Wan, Ye 1; Ma, Haoxiang 1,2; Ma, Zheng 2; Tan, Lili 2; Miao, Lei 3
通讯作者	Wan, Ye(ywan@sjzu.edu.cn) ; Miao, Lei(miaocq777@163.com)
	2023-11-01
发表期刊	ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN	2373-9878
卷号	9 期号:11 页码:6084-6093
摘要	Degradability is vital for bone filling and plays an important role in bone regeneration. Evidence indicates that apatite-based calcium phosphate cement (ACPC) is a prospective biomaterial for bone repair with enhanced osteogenesis. However, poor degradability restricts their clinical application. In this study, MgZnCa-doped ACPC (MgZnCa/ACPC) composites were fabricated by adding 3 (wt) % amorphous MgZnCa powder in the solid phase of ACPC to enhance the biodegradation and bioactivity of the apatite ACPC. The chemical and the physical properties of the MgZnCa/ACPC composite were investigated and compared with the ACPC composite. The results showed that the incorporation of MgZnCa improved both the degradability and the compressive strength of the ACPC composite. X-ray diffraction and Fourier transform infrared spectrometry analysis suggested significant changes in the microstructures of the composites due to the incorporation and the anodic dissolution of MgZnCa alloy. These findings indicate that the MgZnCa/ACPC composite is capable of facilitating bone repair and regeneration by endowing favorable degradation property.
关键词	Fourier transform infrared spectrometer(FTIR) calciumphosphate cement incorporation peak shift degradability
资助者	National Natural Science Foundation of China ; Liaoning Revitalization Talent Program
DOI	10.1021/acsbiomaterials.3c00853
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51971222] ; Liaoning Revitalization Talent Program[XLYC2002005]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:001096824800001
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/177642
专题	中国科学院金属研究所
通讯作者	Wan, Ye; Miao, Lei
作者单位	1.Shenyang Jianzhu Univ, Sch Mat Sci & Engn, Shenyang 110168, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.China Med Univ, Sch Stomatol, Dept Periodont & Oral Biol, Shenyang 110002, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Wan, Ye,Ma, Haoxiang,Ma, Zheng,et al. Enhanced Degradability of the Apatite-Based Calcium Phosphate Cement Incorporated with Amorphous MgZnCa Alloy[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2023,9(11):6084-6093.
APA	Wan, Ye,Ma, Haoxiang,Ma, Zheng,Tan, Lili,&Miao, Lei.(2023).Enhanced Degradability of the Apatite-Based Calcium Phosphate Cement Incorporated with Amorphous MgZnCa Alloy.ACS BIOMATERIALS SCIENCE & ENGINEERING,9(11),6084-6093.
MLA	Wan, Ye,et al."Enhanced Degradability of the Apatite-Based Calcium Phosphate Cement Incorporated with Amorphous MgZnCa Alloy".ACS BIOMATERIALS SCIENCE & ENGINEERING 9.11(2023):6084-6093.