| Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy | |
| Xu Linjie1,2; Liu Hui1; Ren Ling1; Yang Ke1 | |
| 通讯作者 | Yang Ke(kyang@imr.ac.cn) |
| 2023-04-11 | |
| 发表期刊 | ACTA METALLURGICA SINICA
 |
| ISSN | 0412-1961 |
| 卷号 | 59期号:4页码:577-584 |
| 摘要 | Ni-Ti alloys are used widely as a self-expanding vascular stent material because of their unique shape memory effect and superelasticity. However, after implantation, there is a risk of in-stent restenosis (ISR) because of insufficient endothelialization and coagulation problems. As a biological functional metal element, the proper addition of Cu endows vascular stent materials, such as stainless steel and cobalt-based alloys, with significant endothelialization promotion and anticoagulant effect, which can effectively inhibit the occurrence of ISR. Based on the alloying strategy, a biofunctional Ni-Ti-Cu alloy was prepared by adding the proper amount of Cu into medical Ni-Ti alloys. The inhibition effect of ISR and corrosion resistance of the Ni-Ti-Cu alloy were studied via OM, SEM, XRD, surface free energy test, electrochemical test, and in vitro cell experiment. Results showed that compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy promoted the transformation of an equiaxed austenite grain structure to fine lath martensite, reduced the surface free energy, and improved corrosion resistance in simulated human blood. In addition, the extract of the Ni-Ti-Cu alloy could promote the proliferation, migration, and tube formation of human umbilical vein endothelial cells. Furthermore, compared with the Ni-Ti alloy, the Ni-Ti-Cu alloy decreased the blood coagulation rate, presenting better anticoagulation ability, which has an application potential for inhibiting the occurrence of ISR. |
| 关键词 | Ni-Ti alloy Cu in-stent restenosis corrosion resistance |
| 资助者 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province |
| DOI | 10.11900/0412.1961.2022.00553 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Key Research and Development Program of China[2022YFC2406003] ; National Natural Science Foundation of China[81873918] ; National Natural Science Foundation of China[82272099] ; Natural Science Foundation of Liaoning Province[Nos.2021020399-JH2/103] ; Natural Science Foundation of Liaoning Province[2022-YGJC-34] |
| WOS研究方向 | Metallurgy & Metallurgical Engineering |
| WOS类目 | Metallurgy & Metallurgical Engineering |
| WOS记录号 | WOS:000980757300014 |
| 出版者 | SCIENCE PRESS |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/177651 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Yang Ke |
| 作者单位 | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Linjie,Liu Hui,Ren Ling,et al. Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy[J]. ACTA METALLURGICA SINICA,2023,59(4):577-584. |
| APA | Xu Linjie,Liu Hui,Ren Ling,&Yang Ke.(2023).Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy.ACTA METALLURGICA SINICA,59(4),577-584. |
| MLA | Xu Linjie,et al."Effect of Cu on In-Stent Restenosis and Corrosion Resistance of Ni-Ti Alloy".ACTA METALLURGICA SINICA 59.4(2023):577-584. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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