Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy

doi:10.1039/d3nr02088f

IMR OpenIR

	Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy
	Chan, Ming-Hsien 1,2,3; Chen, Bo-Gu 1; Li, Chien-Hsiu 2; Huang, Wen-Tse 1; Su, Ting-Yi 1; Yin, Lichang 4; Hsiao, Michael 2,5; Liu, Ru-Shi 1
通讯作者	Yin, Lichang(lcyin@imr.ac.cn) ; Hsiao, Michael(mhsiao@gate.sinica.edu.tw) ; Liu, Ru-Shi(rsliu@ntu.edu.tw)
	2023-10-05
发表期刊	NANOSCALE
ISSN	2040-3364
卷号	15 期号:38 页码:15558-15572
摘要	Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles. Carbon quantum dots (CDs) have excellent biocompatibility and fluorescence properties as a substrate carrying a single atom. It is difficult to break through pure-phase single-atom materials with quantum dots as carriers. In addition, there is currently no related research in the single-atom field in the context of oral cancer, especially head and neck squamous cell carcinoma. This research developed a lipid surface-coated nanozyme combined with CDs, single-atomic gold, and modified lipid ligands (DSPE-PEG) with transferrin (Tf) to treat oral squamous cell carcinoma. The study results have demonstrated that surface-modified single-atom carbon quantum dots (m-SACDs) exhibit excellent therapeutic effects and enable in situ image tracking for diagnosing and treating head and neck squamous carcinoma (HNSCC). Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles.
资助者	This work was supported by a grant from the National Science and Technology Council in Taiwan (NSTC 109-2113-M-002-020-MY3) to Ru-Shi Liu. Genomics Research Center, Academia Sinica, supported this study with funding for Michael Hsiao. We thank beamlines 01
DOI	10.1039/d3nr02088f
收录类别	SCI
语种	英语
资助项目	This work was supported by a grant from the National Science and Technology Council in Taiwan (NSTC 109-2113-M-002-020-MY3) to Ru-Shi Liu. Genomics Research Center, Academia Sinica, supported this study with funding for Michael Hsiao. We thank beamlines 01
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:001066887100001
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/177681
专题	中国科学院金属研究所
通讯作者	Yin, Lichang; Hsiao, Michael; Liu, Ru-Shi
作者单位	1.Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan 2.Acad Sinica, Genom Res Ctr, Taipei 11529, Taiwan 3.Natl Yang Ming Chiao Tung Univ, Dept Biomed Imaging & Radiol Sci, Taipei 11221, Taiwan 4.Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Natl Taiwan Univ, Dept & Grad Inst Vet Med, Sch Vet Med, Taipei 10617, Taiwan
推荐引用方式 GB/T 7714	Chan, Ming-Hsien,Chen, Bo-Gu,Li, Chien-Hsiu,et al. Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy[J]. NANOSCALE,2023,15(38):15558-15572.
APA	Chan, Ming-Hsien.,Chen, Bo-Gu.,Li, Chien-Hsiu.,Huang, Wen-Tse.,Su, Ting-Yi.,...&Liu, Ru-Shi.(2023).Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy.NANOSCALE,15(38),15558-15572.
MLA	Chan, Ming-Hsien,et al."Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy".NANOSCALE 15.38(2023):15558-15572.