| Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation | |
| Zhao, Yanlong1; Qian, Yifu1; Wang, Haimang1; Zhao, Weiwei1,2,3,4,5; Zhao, Jing6; Zhang, Hongyu1 | |
| Corresponding Author | Zhang, Hongyu(zhanghyu@tsinghua.edu.cn) |
| 2023-05-08 | |
| Source Publication | ACS APPLIED POLYMER MATERIALS
 |
| ISSN | 2637-6105 |
| Volume | 5Issue:6Pages:3999-4010 |
| Abstract | Endowing the implanted biomaterial with a wide range of functions, such as lubrication and antibacterial and anticoagulation properties, is essential for their safe clinical use. In the present study, based on the superlubrication mechanism of articular cartilage, a branched polyelectrolyte polymer (PEI-PMPC) was successfully synthesized based on tert-butyl hydroperoxide-initiated grafting polymerization and then applied to the biocompatible polyurethane (PU) surface. Specifically, the PU sheet was pretreated by polydopamine (PDA), and the PEI-PMPC polymer was grafted onto the PDAmodified PU surface by Schiff base reaction to generate a solid PDA/ PEI-PMPC coating. The unmodified and modified surfaces were characterized by Fourier transform infrared spectroscopy, water contact angle, X-ray photoelectron spectroscopy, and surface zeta potential. To compare the lubrication, antibacterial behavior, and hemocompatibility, the relevant properties of the modified surfaces were evaluated by the tribological test, plate count method, surface morphology, hemolysis rate, activated partial thromboplastin time, and thrombin time. The experimental results demonstrated that the adhesion of bovine serum albumin, Escherichia coli, Staphylococcus aureus, platelets, and red blood cells was significantly decreased on the PEI-PMPC-modified PU surface compared with that of the unmodified PU surface. The multifunctional properties of the coating were attributed to the hydration layer formed by zwitterionic phosphorylcholine groups, and additionally, the cationic PEI served to kill the bacteria adhering to the surface. In summary, the bioinspired coating proposed in this study could potentially be used as a promising surface functionalization strategy for biomedical implants. |
| Keyword | bioinspired coating surface functionalization hydration lubrication antibacterial property anticoagulation |
| Funding Organization | National Natural Science Foundation of China ; Precision Medicine Foundation, Tsinghua University, China ; Capital's Funds for Health Improvement and Research ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China |
| DOI | 10.1021/acsapm.3c00234 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[52022043] ; National Natural Science Foundation of China[52275199] ; Precision Medicine Foundation, Tsinghua University, China[10001020120] ; Capital's Funds for Health Improvement and Research[2020-2Z-40810] ; Research Fund of State Key Laboratory of Tribology, Tsinghua University, China[SKLT2022C18] |
| WOS Research Area | Materials Science ; Polymer Science |
| WOS Subject | Materials Science, Multidisciplinary ; Polymer Science |
| WOS ID | WOS:000988791900001 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/177956 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhang, Hongyu |
| Affiliation | 1.Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol Adv Equipment, Beijing 100084, Peoples R China 2.Shandong Univ, Sch&Hosp Stomatol, Cheeloo Coll Med, Jinan 250012, Shandong, Peoples R China 3.Shandong Univ, Shandong Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 4.Shandong Univ, Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China 5.Shandong Univ, Shandong Prov Clin Res Ctr Oral Dis, Jinan 250012, Shandong, Peoples R China 6.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Yanlong,Qian, Yifu,Wang, Haimang,et al. Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation[J]. ACS APPLIED POLYMER MATERIALS,2023,5(6):3999-4010. |
| APA | Zhao, Yanlong,Qian, Yifu,Wang, Haimang,Zhao, Weiwei,Zhao, Jing,&Zhang, Hongyu.(2023).Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation.ACS APPLIED POLYMER MATERIALS,5(6),3999-4010. |
| MLA | Zhao, Yanlong,et al."Bioinspired Polycation Functionalization of the Polyurethane Surface for Enhanced Lubrication, Antibacterial Property, and Anticoagulation".ACS APPLIED POLYMER MATERIALS 5.6(2023):3999-4010. |
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