Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing

doi:10.1016/j.apmt.2023.101758

IMR OpenIR

	Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing
	Wei, Xuebo 1; Liao, Zhiyong 1; Yang, Liangliang 2; Wu, Fangfang 3,4; Chen, Shaodong 5; Shao, Chuxiao 5; Wang, Xin 6; Xiao, Keshen 7; Xiao, Jian 2; Xu, Ke 1; Sun, Da 1; Zhang, Hongyu 2
通讯作者	Xu, Ke(godxu1987@wzu.edu.cn) ; Sun, Da(sunday@wzu.edu.cn) ; Zhang, Hongyu(hyzhang@wmu.edu.cn)
	2023-04-01
发表期刊	APPLIED MATERIALS TODAY
ISSN	2352-9407
卷号	31 页码:12
摘要	Wound healing is a complex process that can be delayed by persistent inflammatory responses after trauma. Many studies have found that in situ application of biomaterials releases metal ions into wounds to promote wound healing, but the underlying mechanism has not been elucidated. Therefore, we developed a novel nanoscale functional material, phosphorus magnesium fiber (PMF), as a wound dressing to explore its association with wound healing. In this study, in vivo wound healing results showed that PMF accelerated wound closure in full-thickness wound animal models, accompanied by collagen deposition and granulation formation. Moreover, PMF accelerated macrophage polarization by regulating TRPM7-ERK1/2 signaling through the long-term release of magnesium ions into the wound, which contributes to enhancing cell proliferation, growth factor production, and synthesis of ECM in the wound bed, ultimately facilitating wound healing. In vitro studies revealed that PMF promoted the polarization of macrophages to the anti-inflammatory M2 phenotype. Meanwhile, PMF upregulated TRPM7-ERK1/2 expression. In conclusion, our study confirmed the relationship between PMF and macrophage behavior mediated by the TRPM7 channel protein and subsequently investigated the function of PMF in wound healing. This magnesium-based nanofiber material offers an innovative method for treating open wounds and is anticipated to be used as a wound dressing in the field of tissue regeneration.
关键词	Wound healing Phosphorus magnesium fiber Macrophage polarization TRPM7 channel
资助者	National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Lishui City Science and Technology Project ; Wenzhou Science and Technology Innovation Project ; Ningbo Key Research and Development Program
DOI	10.1016/j.apmt.2023.101758
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51901160] ; Zhejiang Provincial Natural Science Foundation of China[LQ22H150004] ; Zhejiang Provincial Natural Science Foundation of China[LY19H030004] ; Lishui City Science and Technology Project[2022GYX30] ; Wenzhou Science and Technology Innovation Project[ZY2020023] ; Wenzhou Science and Technology Innovation Project[ZY2020026] ; Ningbo Key Research and Development Program[2022Z146]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:000995158500001
出版者	ELSEVIER
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/178100
专题	中国科学院金属研究所
通讯作者	Xu, Ke; Sun, Da; Zhang, Hongyu
作者单位	1.Wenzhou Univ, Coll Life & Environm Sci, Wenzhou, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Cixi Biomed Res Inst, Sch Pharmaceut Sci, Wenzhou Wound Repair & Regenerat Key Lab, Wenzhou, Zhejiang, Peoples R China 3.Wenzhou Med Univ, Affiliated Hosp 2, Dept Emergency, Wenzhou, Peoples R China 4.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China 5.Lishui Peoples Hosp, Dept Orthopaed, Lishui, Zhejiang, Peoples R China 6.Ningbo NO6 Hosp, Dept Plast & Reconstruct Surg, Hand & Microsurg, Ningbo, Zhejiang, Peoples R China 7.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China
推荐引用方式 GB/T 7714	Wei, Xuebo,Liao, Zhiyong,Yang, Liangliang,et al. Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing[J]. APPLIED MATERIALS TODAY,2023,31:12.
APA	Wei, Xuebo.,Liao, Zhiyong.,Yang, Liangliang.,Wu, Fangfang.,Chen, Shaodong.,...&Zhang, Hongyu.(2023).Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing.APPLIED MATERIALS TODAY,31,12.
MLA	Wei, Xuebo,et al."Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing".APPLIED MATERIALS TODAY 31(2023):12.