Copper-loaded chitosan coating for improved in-vitro corrosion resistance and endothelialization of magnesium alloy stents

doi:10.1016/j.matchemphys.2023.127931

IMR OpenIR

	Copper-loaded chitosan coating for improved in-vitro corrosion resistance and endothelialization of magnesium alloy stents
	Li, Pengyu 1,2; Ma, Jing 2; Kang, Shumei 1; Chen, Shanshan 2,3
通讯作者	Chen, Shanshan(sschen@imr.ac.cn)
	2023-09-01
发表期刊	MATERIALS CHEMISTRY AND PHYSICS
ISSN	0254-0584
卷号	305 页码:13
摘要	For degradable magnesium alloy stents, excellent corrosion resistance and rapid endothelialization are two essential properties. In this paper, we plan to use a copper-loaded chitosan coating to accelerate the endothelialization process of the stent, which not only improves the biocompatibility of the magnesium alloy stent, but also its corrosion resistance by improving the service environment in vivo. Copper is an impurity in magnesium alloys, so how copper-containing coatings affect the corrosion resistance of magnesium alloy stents is the focus of this paper. The corrosion properties of the material were characterized by electrochemical experiments, immersion experiments, and in vitro cellular experiments characterized the effect of the copper-loaded coating on endothelial cells. The results showed that the Icorr of the copper-loaded chitosan coated sample and the Icorr of the unloaded copper chitosan coated sample were both in the order of 10-8, and the decrease of the corrosion resistance of the magnesium alloy by the copper-containing chitosan composite coating was not significant, and it still had a protective effect on the magnesium alloy substrate. During the immersion process, magnesium and copper ions were slowly released, followed by the hydrogen released. In addition, the weight loss rate of different coated samples presented the tendency of slower at inital, faster at last, and the weight loss rate of 0.041% for the copper-loaded chitosan coated sample was not significantly different from that of 0.035% for the unloaded copper coating group, after 28 days of immersion. The in vitro degradation products of the copper-loaded composite coating on the surface of magnesium alloy were also analyzed by XRD and EPMA, which included Mg(OH)2, Mg3(PO4)2 and Ca3(PO4)2; in addition the degradation process was analyzed. The cellular experiments results showed that the copper-loaded magnesium alloy had a proliferation rate of 243.0% for endothelial cells, which indicated that the copper-loaded coating could endow magnesium alloy stent a good biofunctional properties.
关键词	Magnesium alloy Copper-loaded chitosan coating Copper ions Corrosion resistance Endothelial cell
资助者	National Natural Science Foundation of China ; Youth Innovation Promotion Association, Chinese Academy of Sciences
DOI	10.1016/j.matchemphys.2023.127931
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51901227] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[2019194]
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:001012424000001
出版者	ELSEVIER SCIENCE SA
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/178382
专题	中国科学院金属研究所
通讯作者	Chen, Shanshan
作者单位	1.Univ Sci & Technol Liaoning, Sch Mat & Met, Anshan 114051, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China
推荐引用方式 GB/T 7714	Li, Pengyu,Ma, Jing,Kang, Shumei,et al. Copper-loaded chitosan coating for improved in-vitro corrosion resistance and endothelialization of magnesium alloy stents[J]. MATERIALS CHEMISTRY AND PHYSICS,2023,305:13.
APA	Li, Pengyu,Ma, Jing,Kang, Shumei,&Chen, Shanshan.(2023).Copper-loaded chitosan coating for improved in-vitro corrosion resistance and endothelialization of magnesium alloy stents.MATERIALS CHEMISTRY AND PHYSICS,305,13.
MLA	Li, Pengyu,et al."Copper-loaded chitosan coating for improved in-vitro corrosion resistance and endothelialization of magnesium alloy stents".MATERIALS CHEMISTRY AND PHYSICS 305(2023):13.