| Fabrication and Properties of a Biodegradable Zn-Ca Composite | |
| Zhang, Mengsi1; Wang, Xinyuan1,3; Zhang, Shuo1,4; Wang, Tiebao1; Wang, Xin1; Liu, Shuiqing2; Zhao, Lichen1; Cui, Chunxiang1 | |
| 通讯作者 | Zhao, Lichen(zhlch@hebut.edu.cn) |
| 2023-10-01 | |
| 发表期刊 | MATERIALS
 |
| 卷号 | 16期号:19页码:15 |
| 摘要 | In recent years, Zn and its alloys have become some of the most promising degradable metals as in vivo implants due to their acceptable biocompatibility and more suitable degradation rate compared with Mg-based and Fe-based alloys. However, the degradation rate of Zn-based materials after implantation in the body for orthopedic applications is relatively slow, leading to long-term retention of the implants after fulfilling their missions. Moreover, the excessive release of Zn2+ during the degradation process of Zn-based implants usually leads to high cytotoxicity and delayed osseointegration. To provide a feasible solution to the problem faced by Zn-based implants, a Zn-Ca composite was fabricated by an air pressure infiltration method in this work. The XRD pattern of the composite suggests that the composite is fully composed of Zn-Ca intermetallic compounds. The degradation tests in vitro show that the composite has a much higher degradation rate than pure Zn, and the high Ca content regions in the composite can preferentially degrade as sacrificial anodes. In addition, the composite can efficiently induce Ca-P deposition during immersion tests in Hank's solution. Cytotoxicity tests indicate that L-929 cells exhibit around 82% cell viability (Grade 1) even after being cultured in the 100% extract prepared from the Zn-Ca composite for 1 day and show excellent cell viability. |
| 关键词 | biodegradable metals Zn-Ca composite Zn-Ca intermetallic compound cytotoxicity |
| 资助者 | Science Research Project of Hebei Education Department ; Natural Science Foundation of Hebei Province, China |
| DOI | 10.3390/ma16196432 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Science Research Project of Hebei Education Department[ZD2021034] ; Natural Science Foundation of Hebei Province, China[E2021202140] |
| WOS研究方向 | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics |
| WOS类目 | Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering ; Physics, Applied ; Physics, Condensed Matter |
| WOS记录号 | WOS:001083099500001 |
| 出版者 | MDPI |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/179459 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Zhao, Lichen |
| 作者单位 | 1.Hebei Univ Technol, Sch Mat Sci & Engn, Key Lab New Type Funct Mat Hebei Prov, Tianjin 300130, Peoples R China 2.Hebei Univ Technol, Sch Mech Engn, Tianjin 300130, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Yangzhou Museum, Yangzhou 225126, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Mengsi,Wang, Xinyuan,Zhang, Shuo,et al. Fabrication and Properties of a Biodegradable Zn-Ca Composite[J]. MATERIALS,2023,16(19):15. |
| APA | Zhang, Mengsi.,Wang, Xinyuan.,Zhang, Shuo.,Wang, Tiebao.,Wang, Xin.,...&Cui, Chunxiang.(2023).Fabrication and Properties of a Biodegradable Zn-Ca Composite.MATERIALS,16(19),15. |
| MLA | Zhang, Mengsi,et al."Fabrication and Properties of a Biodegradable Zn-Ca Composite".MATERIALS 16.19(2023):15. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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