Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration

doi:10.1016/j.ijbiomac.2025.141344

IMR OpenIR

	Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration
	Yu, Xinding 1,2; Wang, Jian 3; Zhou, Shenglai 4; Pan, Peng 1,2; Chen, Tiantian 1,2; Wang, Xi 5; Liu, Wentao 1,2
通讯作者	Liu, Wentao(wtliu@imr.ac.cn)
	2025-05-01
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	306 页码:11
摘要	Due to the extreme difficulty of cartilage, we endeavored to fabricate a novel biodegradable scaffold using natural polysaccharide cellulose and poly(lactic-co-glycolic acid) (PLGA) microspheres incorporating controllably released the cartilage inducer kartogenin (KGN) for enhancing regenerative healing in cartilage tissue. Initially, to facilitate the loading of KGN, PLGA/KGN microspheres were fabricated using the solvent volatilization method. These microspheres exhibited high sphericity, with particle sizes diminishing from 12.11 to 3.27 mu m as the emulsification rate increased. Demonstrating adequate encapsulation efficiency, the microspheres enabled controlled drug release, positively influencing cell migration and recruitment. Subsequently, a biodegradable cellulose composite scaffold loaded with PLGA/KGN microspheres was prepared using the freeze-drying method. Compared with pure MCC scaffolds, composite scaffolds had a lower degradation rate, and the incorporation of microspheres promoted cell proliferation and significantly elevated expression of cartilage-related specific genes. In a rat cartilage defect model, it was further demonstrated that the composite scaffold combined with stem cell implantation achieved an optimal repair effect, characterized by vigorous extracellular matrix secretion and increased maturity of the regenerated cartilage tissues, suggesting potential clinical application value as a novel articular cartilage repair product in the future.
关键词	Cartilage defect Microspheres Composite scaffold
资助者	Applied Basic Research Programs of Liaoning Province ; Interdisciplinary Convergence Foundation of Medical Engineering of Natural Science Foundation of Liaoning Province ; Shenyang Na-tional Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences
DOI	10.1016/j.ijbiomac.2025.141344
收录类别	SCI
语种	英语
资助项目	Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Interdisciplinary Convergence Foundation of Medical Engineering of Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Shenyang Na-tional Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences[E01SL607]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001436751900001
出版者	ELSEVIER
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/179745
专题	中国科学院金属研究所
通讯作者	Liu, Wentao
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Jinzhou Med Univ, Dept Orthoped, Affiliated Hosp 1, Jinzhou 121000, Peoples R China 4.China Med Univ, China Lab Anim Ctr, Shenyang 110001, Liaoning, Peoples R China 5.China Med Univ, Sch & Hosp Stomatol, Dept Emergency & Oral Med, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China
推荐引用方式 GB/T 7714	Yu, Xinding,Wang, Jian,Zhou, Shenglai,et al. Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,306:11.
APA	Yu, Xinding.,Wang, Jian.,Zhou, Shenglai.,Pan, Peng.,Chen, Tiantian.,...&Liu, Wentao.(2025).Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,306,11.
MLA	Yu, Xinding,et al."Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 306(2025):11.