In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing

doi:10.1016/j.jma.2023.09.030

IMR OpenIR

	In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing
	Zhang, Wen 1,2; Lu, Jiarui 3; Tan, Lili 2; Ni, Dingrui 2; Zhang, Ran 3; Zhou, Qing 3; Yang, Ke 2; Wang, Qiang 3
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Ni, Dingrui(drni@imr.ac.cn) ; Wang, Qiang(mfqwang@cmu.edu.cn)
	2024-12-01
发表期刊	JOURNAL OF MAGNESIUM AND ALLOYS
ISSN	2213-9567
卷号	12 期号:12 页码:4937-4952
摘要	Biodegradable magnesium-matrix composites (BMMCs) added with bone-like compounds such as hydroxyapatite (HA) have promising orthopedic application potential, but the in vivo results of BMMCs are insufficient, and the difference between in vitro and in vivo are not clarified. In this work, Mg-Zn-Nd-Zr/(10/15/20wt%) HA (Ca10(PO4)6OH2) composites were prepared through friction stirring processing (FSP). It was found that corrosion rate of the composites increased with increase of the HA content, where the corrosion rate from hydrogen evolution of the Mg/10wt% HA was about 0.107 mm/y, showing better corrosion resistance compared with other BMMCs, and the agglomeration of HA powders significantly aggravated the localized corrosion. The ALP specific activity of the MC3T3-E1 cells cultured for 14 days with Mg/10wt% HA (2.12 IU/mg) was higher than that of the matrix (1.85 IU/mg), but there was no difference with the FSP group (2.13 IU/mg). In the early implantation of the rabbit femur, bone volume fraction (BV/TV) of Mg/10wt% HA was 10.69, which was higher than that of the FSP group (6.35). The histological staining showed that the Mg/10wt% HA implant was surrounded by more trabecular bone tissue, exhibiting better osteoinductive regeneration. The Mg-Zn-Nd-Zr/HA composites exhibit higher osteogenic activity in vivo differently from in vitro osteogenic expression. (c) 2023 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer review under responsibility of Chongqing University
关键词	Biodegradable Mg-based composite Friction stir processing Hydroxyapatite Osteogenesis In vivo biodegradation
资助者	National Natural Science Foundation of China ; STS program ; Basic applied research program of Liaoning Province of China
DOI	10.1016/j.jma.2023.09.030
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[51971222] ; STS program[20201600200042] ; Basic applied research program of Liaoning Province of China[2022020347-JH2/1013]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001419760000001
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/180000
专题	中国科学院金属研究所
通讯作者	Tan, Lili; Ni, Dingrui; Wang, Qiang
作者单位	1.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Wen,Lu, Jiarui,Tan, Lili,et al. In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing[J]. JOURNAL OF MAGNESIUM AND ALLOYS,2024,12(12):4937-4952.
APA	Zhang, Wen.,Lu, Jiarui.,Tan, Lili.,Ni, Dingrui.,Zhang, Ran.,...&Wang, Qiang.(2024).In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing.JOURNAL OF MAGNESIUM AND ALLOYS,12(12),4937-4952.
MLA	Zhang, Wen,et al."In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing".JOURNAL OF MAGNESIUM AND ALLOYS 12.12(2024):4937-4952.