Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices

doi:10.1016/j.porgcoat.2025.109108

IMR OpenIR

	Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices
	Qi, Shiqian 1,2; Yan, Hui 1,2; Tang, Ao 1; Li, Ying 1,3
通讯作者	Tang, Ao(a.tang@imr.ac.cn) ; Li, Ying(liying@imr.ac.cn)
	2025-04-01
发表期刊	PROGRESS IN ORGANIC COATINGS
ISSN	0300-9440
卷号	201 页码:13
摘要	Silicone rubber encapsulation materials utilized in implantable electronic devices must withstand a complex biofluidic environment and incorporate a diverse array of inorganic and organic components. Nevertheless, the impact of proteins on the reliability of these encapsulation materials has not been extensively investigated. This study presents a thorough examination of the mechanisms through which proteins influence the performance of silicone rubber encapsulation materials. Initially, it was observed that bovine serum albumin (BSA) adsorbs in an elliptical particulate form, a process facilitated by the presence of peptide bonds (-CO-NH-) and alpha-helical structures, which are functional groups inherent to medical silicone rubber coatings. Additionally, the geometric dimensions of BSA are marginally larger than the microscopic pores of the coating, effectively obstructing water passage through the silicone rubber by blocking these pores. This blockage is crucial for enhancing the encapsulation properties of the coatings, as it significantly inhibits water transport. However, as the coating undergoes cracking, its encapsulation capacity is compromised, allowing for the diffusion of BSA to the T2 copper surface. At this juncture, BSA occupies the adsorption sites of the cathodic reactant O2, thereby effectively inhibiting the corrosion of the metal.
关键词	Organic coatings BSA adsorption Implantable electronic devices Packaging performance
资助者	National Natural Science Foun-dation of China
DOI	10.1016/j.porgcoat.2025.109108
收录类别	SCI
语种	英语
资助项目	National Natural Science Foun-dation of China[52271079] ; National Natural Science Foun-dation of China[51871227]
WOS研究方向	Chemistry ; Materials Science
WOS类目	Chemistry, Applied ; Materials Science, Coatings & Films
WOS记录号	WOS:001424868400001
出版者	ELSEVIER SCIENCE SA
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/180060
专题	中国科学院金属研究所
通讯作者	Tang, Ao; Li, Ying
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 3.Northeastern Univ, Shenyang Natl Lab Mat Sci, 3-11 Wenhua Rd, Shenyang 110819, Peoples R China
推荐引用方式 GB/T 7714	Qi, Shiqian,Yan, Hui,Tang, Ao,et al. Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices[J]. PROGRESS IN ORGANIC COATINGS,2025,201:13.
APA	Qi, Shiqian,Yan, Hui,Tang, Ao,&Li, Ying.(2025).Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices.PROGRESS IN ORGANIC COATINGS,201,13.
MLA	Qi, Shiqian,et al."Unveiling the effect of bovine serum albumin on the packaging performance of medical silicone rubber coating for implantable electronic devices".PROGRESS IN ORGANIC COATINGS 201(2025):13.