A high-performance chitosan-grafted Cu(II) coating improves endothelialization and mitigates the degradation of biodegradable magnesium alloy stents

doi:10.1016/j.biomaterials.2025.123161

IMR OpenIR

	A high-performance chitosan-grafted Cu(II) coating improves endothelialization and mitigates the degradation of biodegradable magnesium alloy stents
	Li, Pengyu 1,4; Qi, Xun 3; Liu, Dexiao 1; Ma, Jing 1; Wang, Shaogang 1; Yang, Ke 1; Yan, Wenhua 2,5; Chen, Shanshan 1
通讯作者	Yan, Wenhua(306331@cqmu.edu.cn) ; Chen, Shanshan(sschen@imr.ac.cn)
	2025-07-01
发表期刊	BIOMATERIALS
ISSN	0142-9612
卷号	318 页码:16
摘要	As biodegradable scaffolds with great application potential, magnesium alloy stents face problems in terms of their fast degradation rate and dysendothelialization of larger meshes. The present solution strategy was to achieve proper and long-term release of Cu(II) ions by preparing a chitosan-grafted Cu(II) coating to promote the endothelialization process and then reduce the degradation rate of magnesium alloy stents by improving their service environment. In this work, the effects of a functional coating on the corrosion resistance, endothelialization and blood compatibility of AZ31 magnesium alloy stents were systematically studied in vitro, and the relevant function of the coated stent was verified by implantation into the rabbit carotid artery. The in vitro results showed that this coating could promote the endothelialization function and blood compatibility of magnesium alloy stents and could maintain adequate corrosion resistance. The in vivo results indicated that endothelization was achieved one week after the implantation of a magnesium alloy stent with a chitosan-grafted Cu(II) coating in the animal carotid artery, and its degradation rate was reduced by 50 %. In addition, this coating could induce the transformation of macrophages into the anti-inflammatory type. Thus, the chitosangrafted Cu(II) coating has been proven to promote the endothelization of magnesium alloy stents, reduce their degradation rate and further inhibit intimal hyperplasia, indicating good application prospects.
关键词	Magnesium alloy stent Chitosan-grafted Cu(II) coating Endothelialization Degradation
资助者	National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Chongqing Science & Technology Commission ; Special Support of Chongqing Postdoctoral Research Project
DOI	10.1016/j.biomaterials.2025.123161
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82272099] ; China Postdoctoral Science Foundation[2022MD713708] ; Chongqing Science & Technology Commission[cstc2021jcyj-bshX0069] ; Special Support of Chongqing Postdoctoral Research Project[2022CQBSHTB3039]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001425579900001
出版者	ELSEVIER SCI LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/180102
专题	中国科学院金属研究所
通讯作者	Yan, Wenhua; Chen, Shanshan
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 2.Chongqing Med & Pharmaceut Coll, Coll Med Technol, Chongqing 401331, Peoples R China 3.China Med Univ, Affiliated Hosp 1, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaoni, Shenyang, Peoples R China 4.Univ Sci & Technol Liaoning, Sch Mat & Met, Anshan, Peoples R China 5.Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China
推荐引用方式 GB/T 7714	Li, Pengyu,Qi, Xun,Liu, Dexiao,et al. A high-performance chitosan-grafted Cu(II) coating improves endothelialization and mitigates the degradation of biodegradable magnesium alloy stents[J]. BIOMATERIALS,2025,318:16.
APA	Li, Pengyu.,Qi, Xun.,Liu, Dexiao.,Ma, Jing.,Wang, Shaogang.,...&Chen, Shanshan.(2025).A high-performance chitosan-grafted Cu(II) coating improves endothelialization and mitigates the degradation of biodegradable magnesium alloy stents.BIOMATERIALS,318,16.
MLA	Li, Pengyu,et al."A high-performance chitosan-grafted Cu(II) coating improves endothelialization and mitigates the degradation of biodegradable magnesium alloy stents".BIOMATERIALS 318(2025):16.