Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film

doi:10.1080/07391102.2024.2328740

IMR OpenIR

	Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film
	Malachy Udowo, Victor 1,2; Unimuke, Tomsmith O.3; Louis, Hitler 3,4; Udoh, Inime Ime 5; Edet, Henry O.3; Okafor, Peter C.3
通讯作者	Malachy Udowo, Victor(victorudowo@mail.ustc.edu.cn) ; Louis, Hitler(Louis.hitler@unical.edu.ng)
	2024-03-09
发表期刊	JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN	0739-1102
页码	14
摘要	Developing a biofilm biomarker detector and inhibitor will immensely benefit efforts geared at curbing infectious diseases and microbiologically induced corrosion of medical implants, marine vessels and buried steel pipelines. N-Acyl homoserine lactones (AHLs) are important biomarkers gram-negative bacteria use for communication. In this work, we investigated the interactions between three AHL molecules and graphene oxide (GO) and ZnO nanomaterials embedded in conjugated poly(3,4-ethylenedioxythiophene) (PEDOT) film. The results show that PEDOT/GO/ZnO detected AHLs to a considerable extent with adsorption enthalpies of -4.02, -4.87 and -4.97 KJ/mol, respectively, for N-(2-oxotetrahydrofuran-3-yl)heptanamide (AHL1), 2-hydroxy-N-(2-oxotetrahydrofuran-3-yl)nonanamide (AHL2) and (E)-3-(3-hydroxyphenyl)-N-(2-oxotetrahydrofuran-3-yl)acrylamide (AHL3) molecules. The ZnO nanoparticles facilitated charge redistribution and transfer, thereby enhancing the conductivity and overall sensitivity of the substrate toward the AHLs. The adsorption distance and sites of interactions further tuned the charge migration and signal generation by the substrate, thus affirming the suitability of the modeled thin film as a sensor material. Excellent stability and conductivity were maintained before and after the adsorption of each AHL molecule. Moreover, the desorption time for each AHL molecule was calculated, and the result affirmed that the modeled film materials are promising for developing highly sensitive biosensors.Communicated by Ramaswamy H. Sarma
关键词	Sensors N-acyl homoserine lactone quorum sensing PEDOT graphene oxide
DOI	10.1080/07391102.2024.2328740
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:001187419300001
出版者	TAYLOR & FRANCIS INC
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/184846
专题	中国科学院金属研究所
通讯作者	Malachy Udowo, Victor; Louis, Hitler
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei, Peoples R China 3.Univ Calabar, Dept Pure & Appl Chem, Calabar, Nigeria 4.Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India 5.Tech Univ Denmark, Dept Chem & Biochem Engn, Kongens Lyngby, Denmark
推荐引用方式 GB/T 7714	Malachy Udowo, Victor,Unimuke, Tomsmith O.,Louis, Hitler,et al. Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film[J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2024:14.
APA	Malachy Udowo, Victor,Unimuke, Tomsmith O.,Louis, Hitler,Udoh, Inime Ime,Edet, Henry O.,&Okafor, Peter C..(2024).Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film.JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,14.
MLA	Malachy Udowo, Victor,et al."Enhanced sensing of bacteria biomarkers by ZnO and graphene oxide decorated PEDOT film".JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2024):14.