Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model

doi:10.1016/j.jma.2022.05.009

IMR OpenIR

	Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model
	Zhang, Baoxiang 1,4; Zhang, Wen 2,3; Zhang, Fei 1,4; Ning, Chao 1,5; An, Mingyang 1,4; Yang, Ke 2; Tan, Lili 2; Zhang, Qiang 1
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Zhang, Qiang(301zq@live.cn)
	2024
发表期刊	JOURNAL OF MAGNESIUM AND ALLOYS
ISSN	2213-9567
卷号	12 期号:1 页码:384-393
摘要	Despite transosseous rotator cuff tear repair using sutures is widely accepted for tendon-bone fixation, the fibrocartilaginous enthesis regeneration is still hardly achieved with the traditional sutures. In the present work, degradable magnesium (Mg) alloy wire was applied to suture supraspinatus tendon in a rat acute rotator cuff tear model with Vicryl Plus 4-0 absorbable suture as control. The shoulder joint humerus-supraspinatus tendon complex specimens were retrieved at 4, 8, and 12 weeks after operation. The Mg alloy suture groups showed better biomechanical properties in terms of ultimate load to failure. Gross observation showed that hyperplastic response of the scar tissue at the tendon-bone interface is progressively alleviated over time in the both Mg alloy suture and Vicryl suture groups. In the histological analysis, for Mg alloy suture groups, chondrocytes appear to proliferate at 4 weeks postoperatively, and the tendon-bone interface showed an orderly structural transition zone at 8 weeks postoperatively. The collagenous fiber tended to be aligned and the tendon-bone interlocking structures apparently formed, where transitional structure from unmineralized fibrocartilage to mineralized fibrocartilage was closer to the native fibrocartilaginous enthesis. In vivo degradation of the magnesium alloy wire was completed within 12 weeks. The results indicated that Mg alloy wire was promising as degradable suture with the potential to promotes fibrocartilaginous interface regeneration in rotator cuff repair. (c) 2022 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) Peer review under responsibility of Chongqing University
关键词	Rotator cuff repair Mg alloy wire Tendon -bone healing Fibrocartilaginous interface.
资助者	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province of China ; DongGuan Innovative Research Team Program ; Military Translational Medicine Fund of Chinese PLA General Hospital ; Capital's Funds for Health Improvement and Research ; DongGuan Science and Technology Service Network Initiative
DOI	10.1016/j.jma.2022.05.009
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2020YFC1107501] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220] ; Natural Science Foundation of Liaoning Province of China[2020 -MS -001] ; DongGuan Innovative Research Team Program[2020607134012] ; Military Translational Medicine Fund of Chinese PLA General Hospital[ZH19008] ; Capital's Funds for Health Improvement and Research[CFH 2022-2-5051] ; DongGuan Science and Technology Service Network Initiative[20201600200042]
WOS研究方向	Metallurgy & Metallurgical Engineering
WOS类目	Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001189060500001
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/184936
专题	中国科学院金属研究所
通讯作者	Tan, Lili; Zhang, Qiang
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Sports Med, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Shi Changxu Innovat Ctr Adv Mat, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.Med Sch PLA, Beijing 100853, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Inst Orthoped, Beijing Key Lab Regenerat Med Orthoped, Key Lab Musculoskeletal Trauma & War Injuries Chin, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Baoxiang,Zhang, Wen,Zhang, Fei,et al. Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model[J]. JOURNAL OF MAGNESIUM AND ALLOYS,2024,12(1):384-393.
APA	Zhang, Baoxiang.,Zhang, Wen.,Zhang, Fei.,Ning, Chao.,An, Mingyang.,...&Zhang, Qiang.(2024).Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model.JOURNAL OF MAGNESIUM AND ALLOYS,12(1),384-393.
MLA	Zhang, Baoxiang,et al."Degradable magnesium alloy suture promotes fibrocartilaginous interface regeneration in a rat rotator cuff transosseous repair model".JOURNAL OF MAGNESIUM AND ALLOYS 12.1(2024):384-393.