Corrosion and Biological Behaviors of Biomedical Ti-24Nb-4Zr-8Sn Alloy under an Oxidative Stress Microenvironment

doi:10.1021/acsami.4c00562

IMR OpenIR

	Corrosion and Biological Behaviors of Biomedical Ti-24Nb-4Zr-8Sn Alloy under an Oxidative Stress Microenvironment
	Liu, Chang 1,2; Yan, Zenglong 3; Yang, Jun 1,2; Wei, Penggong 2; Zhang, Dan 2; Wang, Qiang 2; Zhang, Xing 4; Hao, Yulin 4; Yang, Donghong 1
通讯作者	Zhang, Dan(20052054@cmu.edu.cn) ; Yang, Donghong(yangdonghong@jmsu.edu.cn)
	2024-04-03
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	16 期号:15 页码:18503-18521
摘要	Biomaterials can induce an inflammatory response in surrounding tissues after implantation, generating and releasing reactive oxygen species (ROS), such as hydrogen peroxide (H2O2). The excessive accumulation of ROS may create a microenvironment with high levels of oxidative stress (OS), which subsequently accelerates the degradation of the passive film on the surface of titanium (Ti) alloys and affects their biological activity. The immunomodulatory role of macrophages in biomaterial osteogenesis under OS is unknown. This study aimed to explore the corrosion behavior and bone formation of Ti implants under an OS microenvironment. In this study, the corrosion resistance and osteoinduction capabilities in normal and OS conditions of the Ti-24Nb-4Zr-8Sn (wt %, Ti2448) were assessed. Electrochemical impedance spectroscopy analysis indicated that the Ti2448 alloy exhibited superior corrosion resistance on exposure to excessive ROS compared to the Ti-6Al-4V (TC4) alloy. This can be attributed to the formation of the TiO2 and Nb2O5 passive films, which mitigated the adverse effects of OS. In vitro MC3T3-E1 cell experiments revealed that the Ti2448 alloy exhibited good biocompatibility in the OS microenvironment, whereas the osteogenic differentiation level was comparable to that of the TC4 alloy. The Ti2448 alloy significantly alleviates intercellular ROS levels, inducing a higher proportion of M2 phenotypes (52.7%) under OS. Ti2448 alloy significantly promoted the expression of the anti-inflammatory cytokine, interleukin 10 (IL-10), and osteoblast-related cytokines, bone morphogenetic protein 2 (BMP-2), which relatively increased by 26.9 and 31.4%, respectively, compared to TC4 alloy. The Ti2448 alloy provides a favorable osteoimmune environment and significantly promotes the proliferation and differentiation of osteoblasts in vitro compared to the TC4 alloy. Ultimately, the Ti2448 alloy demonstrated excellent corrosion resistance and immunomodulatory properties in an OS microenvironment, providing valuable insights into potential clinical applications as implants to repair bone tissue defects.
关键词	oxidative stress osteogenesis Ti2448 alloy corrosion inflammation
资助者	Basic Research Project of Basic Scientific Research Fund of Education Department of Heilongjiang ; Scientific Research Funds of the Department of Education of Liaoning Province ; Basic Research Project of the Basic Scientific Research Fund of Education Department of Heilongjiang Province
DOI	10.1021/acsami.4c00562
收录类别	SCI
语种	英语
资助项目	Basic Research Project of Basic Scientific Research Fund of Education Department of Heilongjiang[JYTMS20230113] ; Scientific Research Funds of the Department of Education of Liaoning Province[2023-KYYWF-0612] ; Basic Research Project of the Basic Scientific Research Fund of Education Department of Heilongjiang Province
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:001197343700001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/185179
专题	中国科学院金属研究所
通讯作者	Zhang, Dan; Yang, Donghong
作者单位	1.Jiamusi Univ, Sch Stomatol, Jiamusi 154004, Heilongjiang, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Liaoning, Peoples R China 3.Liaoning Peoples Hosp, Shenyang 110013, Liaoning, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Liu, Chang,Yan, Zenglong,Yang, Jun,et al. Corrosion and Biological Behaviors of Biomedical Ti-24Nb-4Zr-8Sn Alloy under an Oxidative Stress Microenvironment[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(15):18503-18521.
APA	Liu, Chang.,Yan, Zenglong.,Yang, Jun.,Wei, Penggong.,Zhang, Dan.,...&Yang, Donghong.(2024).Corrosion and Biological Behaviors of Biomedical Ti-24Nb-4Zr-8Sn Alloy under an Oxidative Stress Microenvironment.ACS APPLIED MATERIALS & INTERFACES,16(15),18503-18521.
MLA	Liu, Chang,et al."Corrosion and Biological Behaviors of Biomedical Ti-24Nb-4Zr-8Sn Alloy under an Oxidative Stress Microenvironment".ACS APPLIED MATERIALS & INTERFACES 16.15(2024):18503-18521.