Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair

doi:10.1093/rb/rbae051

IMR OpenIR

	Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair
	Wei, Penggong 1,2; Wang, Ning 3; Zhang, Qiyue 1,2; Wang, Wanfeng 1,2; Sun, Hui 1,2; Liu, Zengqian 4; Yan, Tingting 5; Wang, Qiang 1,2; Qiu, Lihong 1,2
通讯作者	Yan, Tingting(yan@kust.edu.cn) ; Wang, Qiang(mfqwang@cmu.edu.cn) ; Qiu, Lihong(lhqiu@cmu.edu.cn)
	2024-06-07
发表期刊	REGENERATIVE BIOMATERIALS
ISSN	2056-3418
卷号	11 页码:16
摘要	Hydroxyapatite (HA) whisker (HAw) represents a distinct form of HA characterized by its high aspect ratio, offering significant potential for enhancing the mechanical properties of bone tissue engineering scaffolds. However, the limited osteoinductivity of HAw hampers its widespread application. In this investigation, we observed HAw-punctured osteoblast membranes and infiltrated the cell body, resulting in mechanical damage to cells that adversely impacted osteoblast proliferation and differentiation. To address this challenge, we developed nano-zinc oxide particle-modified HAw (nano-ZnO/HAw). Acting as a reinforcing and toughening agent, nano-ZnO/HAw augmented the compressive strength and ductility of the matrix materials. At the same time, the surface modification with nano-ZnO particles improved osteoblast differentiation by reducing the mechanical damage from HAw to cells and releasing zinc ion, the two aspects collectively promoted the osteoinductivity of HAw. Encouragingly, the osteoinductive potential of 5% nano-ZnO/HAw and 10% nano-ZnO/HAw was validated in relevant rat models, demonstrating the efficacy of this approach in promoting new bone formation in vivo. Our findings underscore the role of nano-ZnO particle surface modification in enhancing the osteoinductivity of HAw from a physical standpoint, offering valuable insights into the development of bone substitutes with favorable osteoinductive properties while simultaneously bolstering matrix material strength and toughness.
关键词	hydroxyapatite whisker nano-zinc oxide particles surface modification mechanical damage osteoblast differentiation bone defect repair
资助者	National Key R&D Program of China ; Liaoning Medical-Engineering Joint Fund ; Yanglei Academician Expert Workstation of Yunnan Province ; Yunnan Innovation Team of Graphene Mechanism Research and Application Industrialization
DOI	10.1093/rb/rbae051
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2020YFA0710404] ; Liaoning Medical-Engineering Joint Fund[2022-YGJC-01] ; Yanglei Academician Expert Workstation of Yunnan Province[202205AF15025] ; Yunnan Innovation Team of Graphene Mechanism Research and Application Industrialization[202305AS350017]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:001240648700001
出版者	OXFORD UNIV PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/186884
专题	中国科学院金属研究所
通讯作者	Yan, Tingting; Wang, Qiang; Qiu, Lihong
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China 2.Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 3.China Med Univ, Hosp 1, Dept Plast Surg, Shenyang 110001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shi Changxu Innovat Ctr Adv Mat, Shenyang 110016, Peoples R China 5.Kunming Univ Sci & Technol, Fac Mat Sci & Engn, Kunming 650093, Peoples R China
推荐引用方式 GB/T 7714	Wei, Penggong,Wang, Ning,Zhang, Qiyue,et al. Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair[J]. REGENERATIVE BIOMATERIALS,2024,11:16.
APA	Wei, Penggong.,Wang, Ning.,Zhang, Qiyue.,Wang, Wanfeng.,Sun, Hui.,...&Qiu, Lihong.(2024).Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair.REGENERATIVE BIOMATERIALS,11,16.
MLA	Wei, Penggong,et al."Nano-ZnO-modified hydroxyapatite whiskers with enhanced osteoinductivity for bone defect repair".REGENERATIVE BIOMATERIALS 11(2024):16.