Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies

doi:10.1016/j.bioactmat.2024.06.005

IMR OpenIR

	Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies
	Lu, Sihan 2; Wang, Peng 3; Wang, Qingchuan 1,9; Deng, Peng 4; Yuan, Yonghui 5; Fu, Xiaoqing 1; Yang, Yinghui 6; Tan, Lili 1; Yang, Ke 1; Qi, Xun 7,8
通讯作者	Wang, Qingchuan(qcwang11s@imr.ac.cn) ; Yang, Ke(kyang@imr.ac.cn) ; Qi, Xun(qixun716@hotmail.com)
	2024-10-01
发表期刊	BIOACTIVE MATERIALS
卷号	40 页码:34-46
摘要	For gastrointestinal anastomosis, metallic biodegradable staples have a broad application potential. However, both magnesium and zinc alloys have relatively low strength to withstand the repeated peristalsis of the gastrointestinal tract. In this study, we developed a novel kind of biodegradable high-nitrogen iron (HN-Fe) alloy wires (0.23 mm), which were fabricated into the staples. The tensile results showed that the ultimate tensile strength and elongation of HN-Fe wires were 1023.2 MPa and 51.0 %, respectively, which was much higher than those of other biodegradable wires. The degradation rate in vitro of HN-Fe wires was slightly higher than that of pure Fe wires. After 28 days of immersion, the tensile strength of HN-Fe wires remained not less than 240 MPa, meeting the clinical requirements. Furthermore, sixteen rabbits were enrolled to conduct a comparison experiment using HN-Fe and clinical Ti staples for gastroanastomosis. After 6 months of implantation, a homogeneous degradation product layer on HN-Fe staples was observed and no fracture occurred. The degradation rate of HN-Fe staples in vivo was significantly higher than that in vitro, and they were expected to be completely degraded in 2 years. Meanwhile, both benign cutting and closure performance of HN-Fe staples ensured that all the animals did not experience hemorrhage and anastomotic fistula during the observation. The anastomosis site healed without histopathological change, inflammatory reaction and abnormal blood routine and biochemistry, demonstrating good biocompatibility of HN-Fe staples. Thereby, the favorable performance makes the HN-Fe staples developed in this work a promising candidate for gastrointestinal anastomosis.
关键词	High-nitrogen Iron alloy Surgical staples Mechanical property Degradation
资助者	National Natural Science Foundation of China ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center ; STS program ; DongGuan Innovative Research Team Program ; Basic Applied Research Program of Liaoning Province of China
DOI	10.1016/j.bioactmat.2024.06.005
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82272099] ; National Natural Science Foundation of China[51971222] ; National Natural Science Foundation of China[51801220] ; Construction Project of Liaoning Medical Imaging and Interventional Medical Engineering Research Center[18-006-9-01] ; STS program[20201600200042] ; DongGuan Innovative Research Team Program[2020607134012] ; Basic Applied Research Program of Liaoning Province of China[2022020347-JH2/1013] ; Basic Applied Research Program of Liaoning Province of China[2023JH26/103000016]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001250661800001
出版者	KEAI PUBLISHING LTD
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/187218
专题	中国科学院金属研究所
通讯作者	Wang, Qingchuan; Yang, Ke; Qi, Xun
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Sch Intelligent Med, Shenyang 110122, Peoples R China 3.China Med Univ, Dept Intervent Therapy, Hosp 1, Shenyang 110001, Peoples R China 4.China Med Univ, Dept Surg Oncol & Gen Surg, Hosp 1, Shenyang 110001, Peoples R China 5.China Med Univ, Liaoning Canc Hosp & Inst, Canc Hosp, Clin Res Ctr Malignant Tumor Liaoning Prov, Shenyang 110801, Peoples R China 6.Silvan Med Device Co Ltd, Suzhou 215004, Peoples R China 7.China Med Univ, Hosp 1, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaoni, Shenyang 110001, Peoples R China 8.Nanjing North St, Shenyang 110001, Liaoning, Peoples R China 9.Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Lu, Sihan,Wang, Peng,Wang, Qingchuan,et al. Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies[J]. BIOACTIVE MATERIALS,2024,40:34-46.
APA	Lu, Sihan.,Wang, Peng.,Wang, Qingchuan.,Deng, Peng.,Yuan, Yonghui.,...&Qi, Xun.(2024).Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies.BIOACTIVE MATERIALS,40,34-46.
MLA	Lu, Sihan,et al."Biodegradable high-nitrogen iron alloy anastomotic staples: In vitro and in vivo studies".BIOACTIVE MATERIALS 40(2024):34-46.