| Poly(lactide-co-glycolide) microspheres with good biocompatibility | |
| An, Runze1; Tang, Wenmin1; Zhao, Zhanpeng1; Liu, Wentao2; Kan, Liang3 | |
| 通讯作者 | Liu, Wentao(wtliu@imr.ac.cn) ; Kan, Liang(kanliang31cmu@163.com) |
| 2023 | |
| 发表期刊 | ACTA OF BIOENGINEERING AND BIOMECHANICS
 |
| ISSN | 1509-409X |
| 卷号 | 25期号:4页码:111-120 |
| 摘要 | Purpose: Curcumin and icariin have multiple pharmacological effects and are widely used in various fields, but their short half-life, poor bioavailability and low water solubility greatly limit their application in clinical medicine. Poly(lactide-co-glycolide) (PLGA) loaded microspheres not only solve these problems, but also have no toxicity in degradation. Methods: To verify whether PLGA drugloaded microspheres have good biocompatibility, the present experiments used the emulsification-solvent evaporation method to prepare PLGA drug-loaded microspheres and successfully performed the loading of curcumin and icariin. Results: The scanning electron microscopy showed that the particle sizes of the PLGA microspheres were 2-15 lim, icariin/PLGA microspheres were 3-22 lim and curcumin/PLGA microspheres were 5-30 lim. Moreover, the surface of the microspheres was smooth and spherical. Furthermore, the drug loading and encapsulation rate were good. In vitro experiments revealed that the prepared PLGA microspheres were safe and nontoxic, and that they could release drugs stably and slowly. Moreover, their proliferation ability was unaffected after inoculation into bone marrow mesenchymal stem cells (BMSCs), and Alcian blue Staining was performed at last, demonstrating their biocompatibility and important applications in tissue engineering. |
| 关键词 | curcumin icariin PLGA microspheres BMSCs |
| 资助者 | Natural Science Foundation of Liaoning Province ; Ap- plied Basic Research Program of Liaoning Province ; National Materials Science Research Center's Young Talent Program |
| DOI | 10.37190/ABB-02359-2023-06 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Ap- plied Basic Research Program of Liaoning Province[2022JH2/101300104] ; National Materials Science Research Center's Young Talent Program[E01SL607] |
| WOS研究方向 | Biophysics ; Engineering |
| WOS类目 | Biophysics ; Engineering, Biomedical |
| WOS记录号 | WOS:001250249300011 |
| 出版者 | SCIENDO |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/187355 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Liu, Wentao; Kan, Liang |
| 作者单位 | 1.China Med Univ, Shengjing Hosp, Dept Family Med, Shenyang 110004, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 3.China Med Univ, Shengjing Hosp, Dept Geriatr, Shenyang 110004, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | An, Runze,Tang, Wenmin,Zhao, Zhanpeng,et al. Poly(lactide-co-glycolide) microspheres with good biocompatibility[J]. ACTA OF BIOENGINEERING AND BIOMECHANICS,2023,25(4):111-120. |
| APA | An, Runze,Tang, Wenmin,Zhao, Zhanpeng,Liu, Wentao,&Kan, Liang.(2023).Poly(lactide-co-glycolide) microspheres with good biocompatibility.ACTA OF BIOENGINEERING AND BIOMECHANICS,25(4),111-120. |
| MLA | An, Runze,et al."Poly(lactide-co-glycolide) microspheres with good biocompatibility".ACTA OF BIOENGINEERING AND BIOMECHANICS 25.4(2023):111-120. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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