Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell

doi:10.1186/s12951-024-02714-y

IMR OpenIR

	Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell
	Wu, Jie 1,2; Liu, Leyi 1,2; Du, Weidong 1,2; Lu, Yunyang 1,2; Li, Runze 1,2; Wang, Chao 1,2; Xu, Duoling 1,2; Ku, Weili 1,2; Li, Shujun 3; Hou, Wentao 3; Yu, Dongsheng 1,2; Zhao, Wei 1,2
通讯作者	Yu, Dongsheng(yudsh@mail.sysu.edu.cn) ; Zhao, Wei(zhaowei3@mail.sysu.edu.cn)
	2024-07-17
发表期刊	JOURNAL OF NANOBIOTECHNOLOGY
卷号	22 期号:1 页码:24
摘要	Vascularization plays a significant role in promoting the expedited process of bone regeneration while also enhancing the stability and viability of artificial bone implants. Although titanium alloy scaffolds were designed to mimic the porous structure of human bone tissues to facilitate vascularization in bone repair, their biological inertness restricted their broader utilization. The unique attribute of Metal-organic framework (MOF) MIL-53(Fe), known as "breathing", can facilitate the efficient adsorption of extracellular matrix proteins and thus provide the possibility for efficient interaction between scaffolds and cell adhesion molecules, which helps improve the bioactivity of the titanium alloy scaffolds. In this study, MIL-53(Fe) was synthesized in situ on the scaffold after hydrothermal treatment. The MIL-53(Fe) endowed the scaffold with superior protein absorption ability and preferable biocompatibility. The scaffolds have been shown to possess favorable osteogenesis and angiogenesis inducibility. It was indicated that MIL-53(Fe) modulated the mechanotransduction process of endothelial cells and induced increased cell stiffness by promoting the adsorption of adhesion-mediating extracellular matrix proteins to the scaffold, such as laminin, fibronectin, and perlecan et al., which contributed to the activation of the endothelial tip cell phenotype at sprouting angiogenesis. Therefore, this study effectively leveraged the intrinsic "breathing" properties of MIL-53 (Fe) to enhance the interaction between titanium alloy scaffolds and vascular endothelial cells, thereby facilitating the vascularization inducibility of the scaffold, particularly during the sprouting angiogenesis phase. This study indicates that MIL-53(Fe) coating represents a promising strategy to facilitate accelerated and sufficient vascularization and uncovers the scaffold-vessel interaction from a biomechanical perspective.
关键词	Vascularization MIL-53(Fe) Endothelial tip cell Mechanotransduction Cell stiffness
资助者	Natural Science Foundation of Guangdong Province ; National Natural Science Foundation of China ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation [Climbing Program Special Funds]
DOI	10.1186/s12951-024-02714-y
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Guangdong Province ; National Natural Science Foundation of China[82373255] ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation [Climbing Program Special Funds][pdjh2022a0003] ; Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation [Climbing Program Special Funds][pdjh2023a0004] ; [2024A1515012918] ; [2023A1515012554]
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS类目	Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS记录号	WOS:001269996400001
出版者	BMC
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/188350
专题	中国科学院金属研究所
通讯作者	Yu, Dongsheng; Zhao, Wei
作者单位	1.Sun Yat sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangzhou 510055, Peoples R China 2.Sun Yat sen Univ, Guangdong Prov Key Lab Stomatol, Guangzhou 510050, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jie,Liu, Leyi,Du, Weidong,et al. Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell[J]. JOURNAL OF NANOBIOTECHNOLOGY,2024,22(1):24.
APA	Wu, Jie.,Liu, Leyi.,Du, Weidong.,Lu, Yunyang.,Li, Runze.,...&Zhao, Wei.(2024).Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell.JOURNAL OF NANOBIOTECHNOLOGY,22(1),24.
MLA	Wu, Jie,et al."Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell".JOURNAL OF NANOBIOTECHNOLOGY 22.1(2024):24.