Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects

doi:10.1021/acsbiomaterials.4c00949

IMR OpenIR

	Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects
	Yang, Zhongheng 1; Lu, Jiarui 2; Yan, Tao 3; Ibrahim, Muhammad 4,5; Wang, Qingchuan 4; Tan, Lili 4; Wang, Qiang 2; Mu, Yabing 6; Gao, Yuzhong 1
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Gao, Yuzhong(gaoyz@jzmu.edu.cn)
	2024-08-20
发表期刊	ACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN	2373-9878
页码	16
摘要	The repair and regeneration of maxillofacial bone defects are major clinical challenges. Titanium (Ti)-magnesium (Mg) composites are a new generation of revolutionary internal fixation materials encompassing the mechanical strength and bioactive advantages of Ti and Mg alloys, respectively. This study was aimed to construct a Ti-Mg composite internal plate/screw fixation system to fix and repair bone defects. Further, the effects of different internal fixation systems on bone repair were analyzed through radiological and histological analyses. Notably, Ti6Al4V with rolled Mg foil was used as the experimental group, and a bone defect model of transverse complete amputation of the ulna in rabbits similar to the clinical condition was established. The internal fixation system with the highest osteogenic efficiency was selected based on in vivo results, and the direct and indirect bone repair abilities of the selected materials were evaluated in vitro. Notably, the thin Mg foil-Ti6Al4V internal fixation system exhibited the best fixation effect in the bone defect model and promoted the formation of new bone and early healing of bone defect areas. In vitro, the thin Mg foil-Ti6Al4V composite enhanced the activity of MC3T3-E1 cells; promoted the proliferation, adhesion, extension, and osteogenic differentiation of MC3T3-E1 cells; and regulated new bone formation. Further, it also promoted the polarization of RAW264.7 cells to M2 macrophages, induced the osteogenic immune microenvironment, and indirectly regulated the bone repair process. Therefore, a internal fixation system holds a promising potential for the internal fixation of maxillofacial bone defects. Our findings provide a theoretical and scientific basis for the design and clinical application of Ti-Mg internal fixation systems.
关键词	Titanium-magnesium composite Bone defect Bone repair Macrophage polarization Osteogenicdifferentiation
资助者	Liaoning Provincial Natural Science Foundation of China ; Central Guidance Funding for Local Scientific and Technological Development in Liaoning ; Liaoning Department of Education Projects
DOI	10.1021/acsbiomaterials.4c00949
收录类别	SCI
语种	英语
资助项目	Liaoning Provincial Natural Science Foundation of China[2022-MS-212] ; Central Guidance Funding for Local Scientific and Technological Development in Liaoning[2023JH6/100100029] ; Liaoning Department of Education Projects[LJKMZ20221225]
WOS研究方向	Materials Science
WOS类目	Materials Science, Biomaterials
WOS记录号	WOS:001295106500001
出版者	AMER CHEMICAL SOC
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/189149
专题	中国科学院金属研究所
通讯作者	Tan, Lili; Gao, Yuzhong
作者单位	1.Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou 121000, Liaoning, Peoples R China 2.China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang 110001, Peoples R China 3.China Med Univ, Peoples Hosp, Dept Orthoped & Sports Med & Joint Surg, Shenyang 110016, Liaoning, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 6.Umea Univ, Dept Med Biosci, Bldg 6M, SE-90185 Umea, Sweden
推荐引用方式 GB/T 7714	Yang, Zhongheng,Lu, Jiarui,Yan, Tao,et al. Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2024:16.
APA	Yang, Zhongheng.,Lu, Jiarui.,Yan, Tao.,Ibrahim, Muhammad.,Wang, Qingchuan.,...&Gao, Yuzhong.(2024).Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects.ACS BIOMATERIALS SCIENCE & ENGINEERING,16.
MLA	Yang, Zhongheng,et al."Construction of a Titanium-Magnesium Composite Internal Fixation System for Repairing Bone Defects".ACS BIOMATERIALS SCIENCE & ENGINEERING (2024):16.