Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration

doi:10.1021/acsami.4c08737

IMR OpenIR

	Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration
	Pan, Peng 1,2; Wang, Jian 3; Wang, Xi 4; Yu, Xinding 1,2; Chen, Tiantian 1,2; Jiang, Chundong 5; Liu, Wentao 1,2
通讯作者	Liu, Wentao(wtliu@imr.ac.cn)
	2024-09-02
发表期刊	ACS APPLIED MATERIALS & INTERFACES
ISSN	1944-8244
卷号	16 期号:36 页码:47178-47191
摘要	Guided bone regeneration (GBR) technology has been demonstrated to be an effective method for reconstructing bone defects. A membrane is used to cover the bone defect to stop soft tissue from growing into it. The biosurface design of the barrier membrane is key to the technology. In this work, an asymmetric functional gradient Janus membrane was designed to address the bidirectional environment of the bone and soft tissue during bone reconstruction. The Janus membrane was simply and efficiently prepared by the multilayer self-assembly technique, and it was divided into the polycaprolactone isolation layer (PCL layer, GBR-A) and the nanohydroxyapatite/polycaprolactone/polyethylene glycol osteogenic layer (HAn/PCL/PEG layer, GBR-B). The morphology, composition, roughness, hydrophilicity, biocompatibility, cell attachment, and osteogenic mineralization ability of the double surfaces of the Janus membrane were systematically evaluated. The GBR-A layer was smooth, dense, and hydrophobic, which could inhibit cell adhesion and resist soft tissue invasion. The GBR-B layer was rough, porous, hydrophilic, and bioactive, promoting cell adhesion, proliferation, matrix mineralization, and expression of alkaline phosphatase and RUNX2. In vitro and in vivo results showed that the membrane could bind tightly to bone, maintain long-term space stability, and significantly promote new bone formation. Moreover, the membrane could fix the bone filling material in the defect for a better healing effect. This work presents a straightforward and viable methodology for the fabrication of GBR membranes with Janus-based bioactive surfaces. This work may provide insights for the design of biomaterial surfaces and treatment of bone defects.
关键词	guided bone regeneration janus barrier membrane bioactive surfaces stability matrix mineralization
资助者	Applied Basic Research Programs of Liaoning Province ; Natural Science Foundation of Liaoning Province ; Young Talents Project of Shenyang National Laboratory for Materials Science
DOI	10.1021/acsami.4c08737
收录类别	SCI
语种	英语
资助项目	Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Young Talents Project of Shenyang National Laboratory for Materials Science[E01SL607]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:001304120100001
出版者	AMER CHEMICAL SOC
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/189509
专题	中国科学院金属研究所
通讯作者	Liu, Wentao
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 3.Jinzhou Med Univ, Affiliated Hosp 1, Dept Orthoped, Jinzhou 121000, Peoples R China 4.China Med Univ, Sch & Hosp Stomatol, Dept Emergency & Oral Med, Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 5.Chongqing Inst Mesoscop Med Porous Mat, Chongqing 401120, Peoples R China
推荐引用方式 GB/T 7714	Pan, Peng,Wang, Jian,Wang, Xi,et al. Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration[J]. ACS APPLIED MATERIALS & INTERFACES,2024,16(36):47178-47191.
APA	Pan, Peng.,Wang, Jian.,Wang, Xi.,Yu, Xinding.,Chen, Tiantian.,...&Liu, Wentao.(2024).Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration.ACS APPLIED MATERIALS & INTERFACES,16(36),47178-47191.
MLA	Pan, Peng,et al."Barrier Membrane with Janus Function and Structure for Guided Bone Regeneration".ACS APPLIED MATERIALS & INTERFACES 16.36(2024):47178-47191.