Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity

doi:10.3390/toxics12080617

IMR OpenIR

	Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
	Sun, Ziqing 1; Wu, Baihui 2; Yi, Jia 2; Yu, Haiyang 2; He, Jiaxuan 2; Teng, Fei 3; Xi, Tong 1; Zhao, Jinlong 1; Ruan, Jing 2; Xu, Peiye 2; Tao, Runchao 2; Jia, Liushuo 4; Ji, Hao 2
通讯作者	Sun, Ziqing(zqsun@imr.ac.cn) ; Ji, Hao(20180031@wzu.edu.cn)
	2024-08-01
发表期刊	TOXICS
卷号	12 期号:8 页码:17
摘要	Nanoplastics, as emerging environmental pollutants, can transport contaminants across marine environments, polluting pristine ecosystems and being ingested by marine organisms. This transfer poses a severe threat to global aquatic ecosystems and potentially impacts human health through the food chain. Neurobehavioral and reproductive toxicity are critical areas of concern because they directly affect the survival, health, and population dynamics of aquatic species, which can have cascading effects on the entire ecosystem. Using zebrafish as a model organism, we investigated the toxic effects of environmental concentrations of polystyrene nanoplastics (PS-NPs). Behavioral assessments, including the novel tank test and open field test, demonstrated significant neurobehavioral changes, indicating increased anxiety and depressive behaviors. A pathological analysis of brain and gonadal tissues, along with evaluations of neurobehavioral and reproductive toxicity biomarkers, revealed that exposure to PS-NPs leads to brain tissue lesions, inflammatory responses, oxidative stress activation, hormone level disruptions, and gonadal damage. Real-time quantitative PCR studies of reproductive gene expression further showed that PS-NPs disrupt the endocrine regulation pathways of the brain-pituitary-gonadal (BPG) axis, causing reproductive toxicity with sex-specific differences. These findings provide crucial insights into the impacts of nanoplastics on aquatic organisms and their ecological risks, offering theoretical support for future environmental protection and pollutant management efforts.
关键词	environmental pollutants polystyrene nanoplastics reproductive and neurobehavioral effects mechanism oxidative stress
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province ; Natural Science Foundation of Liaoning Province
DOI	10.3390/toxics12080617
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-54] ; Natural Science Foundation of Liaoning Province[2023-MS-025] ; [52101293]
WOS研究方向	Environmental Sciences & Ecology ; Toxicology
WOS类目	Environmental Sciences ; Toxicology
WOS记录号	WOS:001307445200001
出版者	MDPI
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/189686
专题	中国科学院金属研究所
通讯作者	Sun, Ziqing; Ji, Hao
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China 2.Wenzhou Univ, Inst Life Sci & Biomed Collaborat Innovat Ctr Zhej, Wenzhou 325035, Peoples R China 3.Shenyang Aerosp Univ, Civil Aviat Coll, Shenyang 110136, Peoples R China 4.Shenyang Agr Univ, Coll Anim Sci & Vet Med, Shenyang 110866, Peoples R China
推荐引用方式 GB/T 7714	Sun, Ziqing,Wu, Baihui,Yi, Jia,et al. Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity[J]. TOXICS,2024,12(8):17.
APA	Sun, Ziqing.,Wu, Baihui.,Yi, Jia.,Yu, Haiyang.,He, Jiaxuan.,...&Ji, Hao.(2024).Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity.TOXICS,12(8),17.
MLA	Sun, Ziqing,et al."Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity".TOXICS 12.8(2024):17.