3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering

doi:10.1016/j.colsurfb.2024.114199

IMR OpenIR

	3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering
	Tang, Wenmin 1; Pan, Peng 2,3; Chen, Tiantian 2,3; Wang, Jian 4; Cui, Xiangnan 1; Liu, Wentao 2,3; Kan, Liang 1
通讯作者	Liu, Wentao(wtliu@imr.ac.cn) ; Kan, Liang(kanl@sj-hospital.org)
	2025
发表期刊	COLLOIDS AND SURFACES B-BIOINTERFACES
ISSN	0927-7765
卷号	245 页码:9
摘要	Bone defect has always been a difficult problem in clinical work. According to the current research results, tissue engineered scaffolds with a single function, structure, and composition are not sufficient to repair complex bone defects. In this work, a three-dimensional (3D) chitosan degradable composite scaffold loaded with zinc oxide (ZnO) was constructed, and the effect of ZnO content on scaffold performance and osteogenesis was explored. The 3D composite scaffold was prepared by freeze-drying technology. The microstructure, porosity, degradation performance, release performance, swelling performance, cytotoxicity, cell adhesion and osteogenic ability of ZnO nanoparticles and chitosan (ZnONPs/CS) composite scaffolds were measured. The results show that an appropriate amount of ZnO may be helpful to regulate the stability and degradation characteristics of the scaffold to a certain extent. Moreover, the composite scaffold could release ZnO into the simulated body fluid environment. The appropriate amount of ZnO helps to promote the proliferation, adhesion, and osteogenic differentiation of MC3T3-E1 cells. At a ZnO content of 3 wt%, both in vitro and vivo results showed relatively optimal biocompatibility and bioactivity of the scaffolds. This work could at least provide some positive insights for the selection of ZnO dosage, construction of chitosan-based 3D scaffolds, tissue engineering applications, and clinical treatment.
关键词	Zinc oxide nanoparticles Chitosan Tissue engineering scaffold Bone repair
资助者	Natural Science Foundation of Liaoning Province ; Applied Basic Research Programs of Liaoning Province ; Young Talents Project of Shenyang National Laboratory for Materials Science
DOI	10.1016/j.colsurfb.2024.114199
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Young Talents Project of Shenyang National Laboratory for Materials Science[E01SL607]
WOS研究方向	Biophysics ; Chemistry ; Materials Science
WOS类目	Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials
WOS记录号	WOS:001307966000001
出版者	ELSEVIER
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/189746
专题	中国科学院金属研究所
通讯作者	Liu, Wentao; Kan, Liang
作者单位	1.China Med Univ, Shengjing Hosp, Dept Geriatr, Shenyang 110004, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.Jinzhou Med Univ, Affiliated Hosp 1, Dept Orthoped, Jinzhou 121000, Peoples R China
推荐引用方式 GB/T 7714	Tang, Wenmin,Pan, Peng,Chen, Tiantian,et al. 3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2025,245:9.
APA	Tang, Wenmin.,Pan, Peng.,Chen, Tiantian.,Wang, Jian.,Cui, Xiangnan.,...&Kan, Liang.(2025).3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering.COLLOIDS AND SURFACES B-BIOINTERFACES,245,9.
MLA	Tang, Wenmin,et al."3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering".COLLOIDS AND SURFACES B-BIOINTERFACES 245(2025):9.