Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone

doi:10.1016/j.jmrt.2024.09.044

IMR OpenIR

	Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone
	Pan, Peng 1,2; Hao, Lina 3; Tang, Jie 3; Li, Xiao 4; Jiang, Chundong 4; Long, Li 4; Yu, Xinding 1,2; Chen, Tiantian 1,2; Liu, Wentao 1,2
通讯作者	Liu, Wentao(wtliu@imr.ac.cn)
	2024-11-01
发表期刊	JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
ISSN	2238-7854
卷号	33 页码:93-102
摘要	Tantalum (Ta) has good potential for bone tissue engineering due to its excellent corrosion resistance and biocompatibility. However, the customization of Ta-based bone repair materials for irregularly shaped bone defects has been challenging due to their high melting point and hardness. In this work, porous tantalum granules (PTaG) were developed for the first time to repair irregularly shaped bone defects, inspired by the natural phenomenon of sand flow. PTaG were designed as a hierarchical porous structure to regulate the mechanical properties and provide a favorable space for inward growth of cells and tissues. Commercial porous titanium granules (PTiG) and Bio-Oss were used as positive controls to explore the potential of PTaG as bone substitute. The morphology, three-dimensional structure, composition, and mechanical properties of PTaG and PTiG were evaluated by SEM, X-Ray 3D imaging system, 3D laser confocal microscope, EDS, XRD, XPS, and nanoindentation. In vitro, cell compatibility and mineralization ability were evaluated for both materials. Furthermore, PTaG, PTiG, and Bio-Oss were filled in the rabbit femoral defect, and micro-CT and histological analysis were performed after 8 weeks. The results showed that the PTaG had the best bone healing effect due to the hierarchical porous structure, excellent three-dimensional connectivity and chemical stability, suitable mechanical properties and surface roughness, good biocompatibility and mineralization osteogenic activity. This work indicates that PTaG may have a positive potential for filling and repairing irregularly shaped bone defects.
关键词	Tantalum granules Hierarchical pore Bone substitutes Osseointegration
资助者	Natural Science Foundation of Liaoning Province ; Applied Basic Research Programs of Liaoning Province ; Young Talents Project of Shenyang National Laboratory for Materials Science
DOI	10.1016/j.jmrt.2024.09.044
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Liaoning Province[2022-YGJC-02] ; Applied Basic Research Programs of Liaoning Province[2022JH2/101300104] ; Young Talents Project of Shenyang National Laboratory for Materials Science[E01SL607]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001315510600001
出版者	ELSEVIER
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/190056
专题	中国科学院金属研究所
通讯作者	Liu, Wentao
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China 3.Chongqing Runze Pharmaceut Co Ltd, Chongqing 401120, Peoples R China 4.Chongqing Inst Mesoscop Med Porous Mat, Chongqing 401120, Peoples R China
推荐引用方式 GB/T 7714	Pan, Peng,Hao, Lina,Tang, Jie,et al. Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone[J]. JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T,2024,33:93-102.
APA	Pan, Peng.,Hao, Lina.,Tang, Jie.,Li, Xiao.,Jiang, Chundong.,...&Liu, Wentao.(2024).Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone.JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T,33,93-102.
MLA	Pan, Peng,et al."Tantalum granules with hierarchical pore structure for bone regeneration porous tantalum granules repair bone".JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T 33(2024):93-102.