Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development

doi:10.1016/j.cej.2024.155996

IMR OpenIR

	Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development
	Zhang, Xinrui 1; Sun, BeiBei 2; Xi, Tong 1; Zhao, Jinlong 1; Yang, Ke 1; Sun, Siyu 2; Yang, Chunguang 1
通讯作者	Sun, Siyu(sunsy@sj-hospital.org) ; Yang, Chunguang(cgyang@imr.ac.cn)
	2024-11-01
发表期刊	CHEMICAL ENGINEERING JOURNAL
ISSN	1385-8947
卷号	499 页码:12
摘要	Bacterial contamination induced by stubborn biofilms has threatened many industries. Significant efforts have concentrated on mitigating surface-associated biofilms with focus on killing or removing bacterial cells, which are always short duration and suboptimal inhibition on biofilms. Here, we reported a sustainable and nonbiocidal strategy of control biofilms by applying a Cu-bearing stainless steel (SS) to interrupt quorum sensing (QS), mentioned as quorum quenching (QQ). It was found that Cu-bearing SS with the micro-galvanic couples structure consisting of the precipitated Cu-rich phases and the matrix triggers charge transfer reactions with bacteria/ media, resulting in an overexpression of reactive oxygen species (ROS), which is responsible for QQ. Studies with luxS-delated mutant which cannot mediate the QS mechanism confirmed that QS could be the target for antibacterial metals to produce a sub-/non-lethal biofilm structural inhibition. And inducing ROS production has been a strategy to endow metals with QQ ability. Thereby, defective biofilms with the QS deletion phenotype would be gratifying to provide a sufficient window period for effective decontamination, curbing the solid surface as for contamination spreader. This research introduces a promising and practical QQ strategy for combating bacterial contamination from the root in active microbial environments, providing insights into the material modifications.
关键词	Biofilms Quorum quenching Cu-bearing stainless steel Reactive oxygen species
资助者	National Natural Science Foundation of China ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine ; Technology Innovation of Foshan City ; IMR Innovation Fund ; Research and Development of Special Stainless Steel for Medical Use with High Strength and Corrosion Resistant
DOI	10.1016/j.cej.2024.155996
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52101293] ; National Natural Science Foundation of China[52001311] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-54] ; Peak Climbing Project of Foshan Hospital of Traditional Chinese Medicine[202000206] ; Technology Innovation of Foshan City[2020001004942] ; IMR Innovation Fund[2022-PY18] ; Research and Development of Special Stainless Steel for Medical Use with High Strength and Corrosion Resistant[2024C01151]
WOS研究方向	Engineering
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS记录号	WOS:001327764600001
出版者	ELSEVIER SCIENCE SA
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/190392
专题	中国科学院金属研究所
通讯作者	Sun, Siyu; Yang, Chunguang
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xinrui,Sun, BeiBei,Xi, Tong,et al. Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development[J]. CHEMICAL ENGINEERING JOURNAL,2024,499:12.
APA	Zhang, Xinrui.,Sun, BeiBei.,Xi, Tong.,Zhao, Jinlong.,Yang, Ke.,...&Yang, Chunguang.(2024).Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development.CHEMICAL ENGINEERING JOURNAL,499,12.
MLA	Zhang, Xinrui,et al."Quorum quenching as a mechanism for Cu-bearing stainless steel to conduct nonbiocidal retardation of biofilm development".CHEMICAL ENGINEERING JOURNAL 499(2024):12.