Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing

doi:10.1016/j.mtbio.2024.101266

IMR OpenIR

	Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing
	Chen, Siwen 1,2; Li, Yutong 3; Ren, Sihang 4; Yang, Yuanyuan 2; Hou, Zhipeng 2; Han, Siyu 1; Zhang, Wanhong 1; Guo, Jing 5; Hu, Jianshe 1; Zhang, Xing 3; Yang, Liqun 2
通讯作者	Hu, Jianshe(hujs@mail.neu.edu.cn) ; Zhang, Xing(xingzhang@imr.ac.cn) ; Yang, Liqun(yangliqun@sj-hospital.org)
	2024-12-01
发表期刊	MATERIALS TODAY BIO
ISSN	2590-0064
卷号	29 页码:14
摘要	Skin trauma is a matter of great concern for public health, emphasizing the importance of reconstructing the microenvironment at the trauma site to facilitate tissue regeneration. Therefore, the investigation of innovative wound dressings has significant research and clinical implications. In this study, we prepared a thermosensitive hydrogel based on a hydrophilic-hydrophobic-hydrophilic triblock polycarbonate polymer (PTP), and created a composite hydrogel, PTPH-AZP, by incorporating amorphous zinc phosphate (AZP) nanoclusters. We evaluated the effects of PTPH-AZP on human umbilical vein endothelial cells (HUVECs) and the ability to promote skin wound healing. According to the results, PTPH-AZP was found to promote the proliferation, migration, and tube formation of HUVECs through the sustained release of Zn2+ at appropriate concentrations. In vivo experiments demonstrated that in the early-mid stages of wound healing, PTPH-AZP promotes increases in Platelet Endothelial Cell Adhesion Molecule-1 (CD31) and alpha-Smooth Muscle Actin (alpha-SMA) content within the wound area, facilitating accelerated re-epithelialization and enhanced collagen deposition. In later healing stages, epidermal thickness in the PTPH-AZP treated group was significantly improved, aligning with surrounding intact skin with no instances of attenuated or hypertrophic scarring observed. The findings from the in vivo study suggested that PTPH-AZP may have a positive impact on vascularization and wound healing. In conclusion, this study presents a promising strategy for skin wound healing, highlighting the potential of PTPH-AZP as an effective therapeutic approach.
关键词	Thermosensitive hydrogel Polycarbonate Amorphous zinc phosphate Vascularization Wound healing
资助者	Natural Science Foundation of Liaoning Province ; Support Program for Excel-lent Young Scholars of China Medical University ; Fundamental Research Funds for the Central Universities
DOI	10.1016/j.mtbio.2024.101266
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Liaoning Province[2022-YGJC-69] ; Support Program for Excel-lent Young Scholars of China Medical University ; Fundamental Research Funds for the Central Universities[N2305004]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001327056200001
出版者	ELSEVIER
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/190435
专题	中国科学院金属研究所
通讯作者	Hu, Jianshe; Zhang, Xing; Yang, Liqun
作者单位	1.Northeastern Univ, Coll Sci, Ctr Mol Sci & Engn, Shenyang 110819, Peoples R China 2.China Med Univ, Shengjing Hosp, Res Ctr Biomed Mat, Engn Res Ctr,Minist Educ Minimally Invas Gastroint, Shenyang 110004, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 4.Dalian Med Univ, Hosp 2, Dept Plast Surg, Dalian 116027, Peoples R China 5.China Med Univ, Liaoning Res Inst Eugen Birth & Fertil, Shenyang 110031, Peoples R China
推荐引用方式 GB/T 7714	Chen, Siwen,Li, Yutong,Ren, Sihang,et al. Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing[J]. MATERIALS TODAY BIO,2024,29:14.
APA	Chen, Siwen.,Li, Yutong.,Ren, Sihang.,Yang, Yuanyuan.,Hou, Zhipeng.,...&Yang, Liqun.(2024).Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing.MATERIALS TODAY BIO,29,14.
MLA	Chen, Siwen,et al."Amorphous zinc phosphate nanoclusters loaded polycarbonate thermosensitive hydrogel: An innovative strategy for promoting wound healing".MATERIALS TODAY BIO 29(2024):14.