Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing

doi:10.1016/j.jot.2024.08.003

IMR OpenIR

	Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing
	Ma, Yutong 2; Wang, Yi 3; Tong, Shuang 1; Wang, Yuehan 3; Wang, Zhuoya 3; Sui, Rongze 3; Yang, Ke 4; Witte, Frank 5; Yang, Shude 1
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Witte, Frank(frank.witte@charite.de) ; Yang, Shude(sdyang@cmu.edu.cn)
	2024-11-01
发表期刊	JOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN	2214-031X
卷号	49 页码:135-155
摘要	Background: Porous metal materials have been widely studied for applications in orthopedic field, owing to their excellent features and properties in bone healing. Porous metal materials with different compositions, manufacturing methods, and porosities have been developed. Whereas, the systematic mechanisms on how porous metal materials promote bone healing still remain unclear. Methods: This review is concerned on the porous metal materials from three aspects with accounts of specific mechanisms, inflammatory regulation, angiogenesis and osteogenesis. We place great emphasis on different cells regulated by porous metal materials, including mesenchymal stem cells (MSCs), macrophages, endothelial cells (ECs), etc. Result: The design of porous metal materials is diversified, with its varying pore sizes, porosity material types, modification methods and coatings help researchers create the most experimentally suitable and clinically effective scaffolds. Related signal pathways presented from different functions showed that porous metal materials could change the behavior of cells and the amount of cytokines, achieving good influence on osteogenesis. Conclusion: This article summarizes the current progress achieved in the mechanism of porous metal materials promoting bone healing. By modulating the cellular behavior and physiological status of a spectrum of cellular constituents, such as macrophages, osteoblasts, and osteoclasts, porous metal materials are capable of activating different pathways and releasing regulatory factors, thus exerting pivotal influence on improving the bone healing effect. The translational potential of this article: Porous metal materials play a vital role in the treatment of bone defects. Unfortunately, although an increasing number of studies have been concentrated on the effect of porous metal materials on osteogenesis-related cells, the comprehensive regulation of porous metal materials on the host cell functions during bone regeneration and the related intrinsic mechanisms remain unclear. This review summarizes different design methods for porous metal materials to fabricate the most suitable scaffolds for bone remodeling, and systematically reviews the corresponding mechanisms on inflammation, angiogenesis and osteogenesis of porous metal materials. This review can provide more theoretical framework and innovative optimization for the application of porous metal materials in orthopedics, dentistry, and other areas, thereby advancing their clinical utility and efficacy.
关键词	Angiogenesis Bone regeneration Immunomodulation Osteogenesis Porous metal materials
资助者	National Natural Science Foundation of China
DOI	10.1016/j.jot.2024.08.003
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82301045]
WOS研究方向	Orthopedics
WOS类目	Orthopedics
WOS记录号	WOS:001335232000001
出版者	ELSEVIER
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/190803
专题	中国科学院金属研究所
通讯作者	Yang, Ke; Witte, Frank; Yang, Shude
作者单位	1.China Med Univ, Dept Plast Surg, Hosp 1, Shenyang 110001, Peoples R China 2.China Med Univ, Dept Breast Surg, Hosp 1, Shenyang 110001, Peoples R China 3.China Med Univ, Clin Coll 1, Shenyang 110001, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Charite Med Univ, Dept Prosthodont Geriatr Dent & Craniomandibular D, Assmannshauser Str 4-6, D-14197 Berlin, Germany
推荐引用方式 GB/T 7714	Ma, Yutong,Wang, Yi,Tong, Shuang,et al. Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2024,49:135-155.
APA	Ma, Yutong.,Wang, Yi.,Tong, Shuang.,Wang, Yuehan.,Wang, Zhuoya.,...&Yang, Shude.(2024).Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing.JOURNAL OF ORTHOPAEDIC TRANSLATION,49,135-155.
MLA	Ma, Yutong,et al."Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing".JOURNAL OF ORTHOPAEDIC TRANSLATION 49(2024):135-155.