| Evaluating the Biodegradability and Cellular Compatibility of Mg-Zn-Nd Alloy for Vascular Stent Application | |
| Xing, Yiqi1,2; Tan, Lili3; Ma, Zheng3; Zhu, Tingzhun1; Liang, Guobiao1 | |
| 通讯作者 | Zhu, Tingzhun(zhutingzhun2000@aliyun.com) |
| 2024-11-11 | |
| 发表期刊 | ADVANCED BIOLOGY
 |
| ISSN | 2701-0198 |
| 页码 | 9 |
| 摘要 | The study is designed to evaluate the corrosion behavior, biocompatibility, and cytotoxicity of a novel magnesium alloy, Mg-2Zn-0.5Nd (ZN20), for potential use as biodegradable scaffolding in cerebrovascular stents. Magnesium alloy (AZ31) and ZN20 are co-cultured with Human Umbilical Vein Endothelial Cells (HUVEC) and human neuroblastoma cell (SH-SY5Y), respectively. The corrosion of AZ31 and ZN20 in different time periods is detected by electron microscope, the effects of AZ31 and ZN20 on the expression level of inflammatory factors are detected by ELISA, the PH value of cells in each group is detected, and the cell proliferation is detected by cck-8. Cell-related apoptosis protein, the expression of Platelet endothelial cell adhesion molecule-1 (CD31) and VE-cad is detected, and the pathological analysis of rat vascular tissue is carried out by HE experiment. In contrast to the AZ31 group, ZN20 exhibits mild, uniform corrosion and does not significantly deter HUVEC proliferation or increase inflammatory markers and In vivo testing reveals better endothelization with ZN20, as demonstrated by higher expression of endothelial markers CD31, and intact endothelial structure group. Western blotting shows favorable expression levels of apoptotic and anti-apoptotic markers in the ZN20 group. ZN20 alloy demonstrates enhanced corrosion resistance, favorable endothelial compatibility, and reduced cytotoxicity, endorsing its safe application in vascular stent use. |
| 关键词 | biodegradation metal cellular compatibility magnesium alloy stent material |
| 资助者 | Natural Science Foundation of Liaoning Province |
| DOI | 10.1002/adbi.202400165 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | Natural Science Foundation of Liaoning Province[2022-YGJC-13] |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| WOS记录号 | WOS:001354179400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/191492 |
| 专题 | 中国科学院金属研究所 |
| 通讯作者 | Zhu, Tingzhun |
| 作者单位 | 1.Gen Hosp Northern Theater Command, Inst Neurosci, 83 Wenhua Rd, Shenyang 110016, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 2, Dalian 116044, Liaoning, Peoples R China 3.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xing, Yiqi,Tan, Lili,Ma, Zheng,et al. Evaluating the Biodegradability and Cellular Compatibility of Mg-Zn-Nd Alloy for Vascular Stent Application[J]. ADVANCED BIOLOGY,2024:9. |
| APA | Xing, Yiqi,Tan, Lili,Ma, Zheng,Zhu, Tingzhun,&Liang, Guobiao.(2024).Evaluating the Biodegradability and Cellular Compatibility of Mg-Zn-Nd Alloy for Vascular Stent Application.ADVANCED BIOLOGY,9. |
| MLA | Xing, Yiqi,et al."Evaluating the Biodegradability and Cellular Compatibility of Mg-Zn-Nd Alloy for Vascular Stent Application".ADVANCED BIOLOGY (2024):9. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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