Anti-infective Ti-Cu alloy inhibits bacterial drug resistance

doi:10.1016/j.matlet.2024.137736

IMR OpenIR

	Anti-infective Ti-Cu alloy inhibits bacterial drug resistance
	Xu, Zhiqiang 1; Liu, Min 2,3; Zhao, Na 1; Chen, Guocai 1; Lu, Weicheng 4; Li, Haixin 1; Wu, Yuanyan 1; Tan, Hao 1; Yang, Chunguang 2; Zhang, Xinrui 2
通讯作者	Zhang, Xinrui(xrzhang16s@imr.ac.cn)
	2025-01-15
发表期刊	MATERIALS LETTERS
ISSN	0167-577X
卷号	379 页码:4
摘要	Implant-associated infection is mainly conducted with antibiotics in clinic. However, the overuse and abuse of antibiotics contributes to resistant infections, increasing the difficulty of treatment. In this work, we initially investigate the effect of anti-infective Ti-Cu alloy incorporating with antibiotics (ciprofloxacin) to inhibit methicillin-resistant Staphylococcus aureus (MRSA) infections. Results show that, for Drug + Ti-Cu alloy group, the minimum inhibitory concentration (MIC) of antibiotics reduces by 76.00 %, minimum bactericidal concentration (MBC) reduces by 75.00 % and IC50 reduces by 77.77 %. Scanning electron microscope (SEM) and laser confocal scanning microscope (CLSM) observations demonstrate that Ti-Cu alloy inhibits biofilms, including inhibiting bacterial activity and extracellular polymer substrates (EPS) secretion. We conclude high redox oxygen species (ROS) expression contributes to the excellent anti-infection capabilities of Ti-Cu alloy. Our work opens an avenue for addressing persistent drug resistant bacterial infections.
关键词	Adhesion Biomaterials Metals and alloys Implant-associated infections Ti-Cu alloy Antibiotics
资助者	Hospital of Traditional Chinese Medicine ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province
DOI	10.1016/j.matlet.2024.137736
收录类别	SCI
语种	英语
资助项目	Hospital of Traditional Chinese Medicine[202000206] ; National Natural Science Foundation of China[52301307] ; National Natural Science Foundation of China[52171242] ; Natural Science Foundation of Liaoning Province[2024-BSBA-48] ; Natural Science Foundation of Medical and Industrial Cross Joint of Liaoning Province[2022-YGJC-49]
WOS研究方向	Materials Science ; Physics
WOS类目	Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:001361137700001
出版者	ELSEVIER
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/191739
专题	中国科学院金属研究所
通讯作者	Zhang, Xinrui
作者单位	1.Foshan Hosp Tradit Chinese Med, Inst Orthoped & Traumatol, Foshan 528000, Peoples R China 2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.China Med Univ, Dept Neurosurg, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Xu, Zhiqiang,Liu, Min,Zhao, Na,et al. Anti-infective Ti-Cu alloy inhibits bacterial drug resistance[J]. MATERIALS LETTERS,2025,379:4.
APA	Xu, Zhiqiang.,Liu, Min.,Zhao, Na.,Chen, Guocai.,Lu, Weicheng.,...&Zhang, Xinrui.(2025).Anti-infective Ti-Cu alloy inhibits bacterial drug resistance.MATERIALS LETTERS,379,4.
MLA	Xu, Zhiqiang,et al."Anti-infective Ti-Cu alloy inhibits bacterial drug resistance".MATERIALS LETTERS 379(2025):4.