Tailoring the corrosion resistance and biological performance of Mg-Zn-Y-Nd bioimplants with multiphasic, pore-sealed cerium-doped ceramic coatings via facile one-pot plasma electrolytic oxidation

doi:10.1016/j.jmst.2025.01.016

IMR OpenIR

	Tailoring the corrosion resistance and biological performance of Mg-Zn-Y-Nd bioimplants with multiphasic, pore-sealed cerium-doped ceramic coatings via facile one-pot plasma electrolytic oxidation
	Zhao, Chaochao 1,2; Wen, Min 1,2; Wang, Qiaoli 1; Ouyang, Wentai 3; Xu, Daokui 4; Jia, Zhaojun 5; Zheng, Yufeng 2; Xi, Tingfei 1; Sheng, Liyuan 1,2
通讯作者	Jia, Zhaojun(jiazhj@mail.sysu.edu.cn) ; Sheng, Liyuan(lysheng@yeah.net)
	2025-09-20
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	230 页码:60-79
摘要	Magnesium alloys have illustrated great promise for building biodegradable implantable devices due to their unique combination of biocompatibility, mechanical properties, and degradable absorption characteristics. However, the uncontrollably fast degradation in physiological environments remains a humongous challenge restraining their clinical application, requiring engineering strategies such as surface modification for biocorrosion and biofunctionality optimization. Herein, CeO2 nanoparticle-doped plasma electrolytic oxidation (PEO) coatings were applied to surface modify a novel Mg-Zn-Y-Nd alloy. During the PEO process, nanocrystal CeO2 nanoparticles, alongside the newly formed secondary corrosion-resistant (CePO4) phase, sealed the micropores of the PEO coatings under discharge, affording enhanced barrier effects against biocorrosion. Electrochemical tests in Hank's solution showed a remarkable increase in corrosion potential and charge transfer resistance and a decrease in corrosion current density. Further characterization showed that a dense anti-corrosion coating of Mg(OH)2/CeO2/Ce(OH)3 was formed, effectively limiting the attacks of corrosive mediums and ensuring controlled degradation. The coatingfunctionalized implants, as reveled in vitro and in ovo, were compatible with NIH3T3 fibroblasts, HUVECs, red blood cells, and chick chorioallantoic membranes, with even enhanced pro-healing effects in scratch- based wound models. Overall, this work highlights the potential of CeO2-doped PEO coatings to fine-tune the corrosion resistance and biocompatibility of Mg-Zn-Y-Nd alloys for biomaterial implants. (c) 2025 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
关键词	Mg-Zn-Y-Nd alloy PEO coating Slow degradation Biocompatibility CeO2 nanoparticle doping
资助者	Guangdong Basic and Applied Basic Research Foundation ; IER Foundation
DOI	10.1016/j.jmst.2025.01.016
收录类别	SCI
语种	英语
资助项目	Guangdong Basic and Applied Basic Research Foundation[2023A1515012951] ; IER Foundation[IERF202201] ; IER Foundation[IERF202202] ; IER Foundation[IERF202102]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001442815500001
出版者	ELSEVIER
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/192013
专题	中国科学院金属研究所
通讯作者	Jia, Zhaojun; Sheng, Liyuan
作者单位	1.PKU HKUST Shenzhen Hongkong Inst, Shenzhen 518057, Peoples R China 2.Peking Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China 3.Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Sun Yat Sen Univ, Sch Biomed Engn, Shenzhen Campus, Shenzhen 518107, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Chaochao,Wen, Min,Wang, Qiaoli,et al. Tailoring the corrosion resistance and biological performance of Mg-Zn-Y-Nd bioimplants with multiphasic, pore-sealed cerium-doped ceramic coatings via facile one-pot plasma electrolytic oxidation[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2025,230:60-79.
APA	Zhao, Chaochao.,Wen, Min.,Wang, Qiaoli.,Ouyang, Wentai.,Xu, Daokui.,...&Sheng, Liyuan.(2025).Tailoring the corrosion resistance and biological performance of Mg-Zn-Y-Nd bioimplants with multiphasic, pore-sealed cerium-doped ceramic coatings via facile one-pot plasma electrolytic oxidation.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,230,60-79.
MLA	Zhao, Chaochao,et al."Tailoring the corrosion resistance and biological performance of Mg-Zn-Y-Nd bioimplants with multiphasic, pore-sealed cerium-doped ceramic coatings via facile one-pot plasma electrolytic oxidation".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 230(2025):60-79.