Biodegradable Magnesium alloy Janus membrane with surface-selective osteoinduction and soft tissue healing properties in guided bone regeneration

doi:10.1016/j.actbio.2025.02.001

IMR OpenIR

	Biodegradable Magnesium alloy Janus membrane with surface-selective osteoinduction and soft tissue healing properties in guided bone regeneration
	Han, Yujia 1,2; Wang, Xiaoxia 3,4; Wei, Penggong 1,2; Zhang, Dan 1,2; Gao, Ming 4; Yu, Zihang 1,2; Wang, Qiang 1,2; Tan, Lili 3,4; Tian, Yulou 1,2
通讯作者	Zhang, Dan(20052054@cmu.edu.cn) ; Tan, Lili(lltan@imr.ac.cn) ; Tian, Yulou(yltian@cmu.edu.cn)
	2025-03-15
发表期刊	ACTA BIOMATERIALIA
ISSN	1742-7061
卷号	195 页码:582-598
摘要	Given that the guided bone regeneration (GBR) membrane acts at the interface between the bone and connective tissue, the membrane imposes high demands on the organization of the material. Magnesium (Mg) alloys have emerged as promising candidates for GBR due to their biodegradability and favorable biocompatibility. However, challenges remain in the risk of soft tissue dehiscence and limited osteogenesis for Mg membranes in the clinical application. A dicalcium phosphate dihydrate (CaHPO4 & sdot;2H2O, denoted as DCPD)/MgF2 Janus membrane was fabricated via chemical conversion and deposition, showcasing suitable degradability, surface-selective osteogenic property and soft tissue healing in vitro and vivo. The DCPD coating was designed to support osteogenesis, while the MgF2 coating was specifically engineered to facilitate soft tissue healing. Furthermore, the Janus membrane utilized its two-sided properties to show selectivity in adhesion, proliferation, and migration of the MC3T3-E1 and HGFs. In vivo results exhibited its capability to promote bone formation and optimal space maintenance ability. Notably, further RNA-seq analysis demonstrated that different functional cells may respond specifically to two coatings and exert functions. Taken together, these results provide an alternative method for designing surface-selective biomaterials, underlining effective potential applications in bone tissue engineering. Statement of significance: Traditional clinical treatment of bone defects with GBR membranes is frequently constrained to a single superimposed osteogenesis without structural-functional integration. Such a DCPD/MgF2 coated Janus membrane was fabricated by incorporating chemical deposition and transformation to satisfy optimal osteogenesis and soft tissue healing. Of particular interest, the Janus membrane allowed for chemotactic movement with specific cellular responses to stimuli from different coatings. In vivo, the membrane demonstrated promising effects and showcased space maintenance ability. The design concept exhibits a new avenue to regulate tissue regeneration between different tissue interface, presenting new horizons for the development of GBR membranes.
关键词	Guided bone regeneration Osteogenesis Soft tissue healing Magnesium alloy
资助者	National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Project of Liaoning Province ; Basic Applied Research Program of Liaoning Province of China ; Dongguan Innovative Research Team Program ; Zhenghai Biological
DOI	10.1016/j.actbio.2025.02.001
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2024YFC2418600] ; National Natural Science Foundation of China[52471265] ; National Natural Science Foundation of China[52201302] ; Science and Technology Project of Liaoning Province[2024 JH6/100800013] ; Basic Applied Research Program of Liaoning Province of China[2022020347-JH2/1013] ; Dongguan Innovative Research Team Program ; Zhenghai Biological
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001448269900001
出版者	ELSEVIER SCI LTD
引用统计
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/192097
专题	中国科学院金属研究所
通讯作者	Zhang, Dan; Tan, Lili; Tian, Yulou
作者单位	1.China Med Univ, Sch & Hosp Stomatol, Shenyang 110002, Peoples R China 2.Liaoning Prov Key Lab Oral Dis, Shenyang 110002, Peoples R China 3.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Peoples R China 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Han, Yujia,Wang, Xiaoxia,Wei, Penggong,et al. Biodegradable Magnesium alloy Janus membrane with surface-selective osteoinduction and soft tissue healing properties in guided bone regeneration[J]. ACTA BIOMATERIALIA,2025,195:582-598.
APA	Han, Yujia.,Wang, Xiaoxia.,Wei, Penggong.,Zhang, Dan.,Gao, Ming.,...&Tian, Yulou.(2025).Biodegradable Magnesium alloy Janus membrane with surface-selective osteoinduction and soft tissue healing properties in guided bone regeneration.ACTA BIOMATERIALIA,195,582-598.
MLA	Han, Yujia,et al."Biodegradable Magnesium alloy Janus membrane with surface-selective osteoinduction and soft tissue healing properties in guided bone regeneration".ACTA BIOMATERIALIA 195(2025):582-598.