NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy

doi:10.1038/s41467-025-57188-9

IMR OpenIR

	NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy
	Dai, Hao 1,2,3,4,5,6,7; Han, Ali 8,9; Wang, Xijun 10; Zhu, Peng 8; Wang, Dingsheng 8; Wang, Yuguang 1
通讯作者	Han, Ali(hanali@mail.ustc.edu.cn) ; Wang, Dingsheng(wangdingsheng@mail.tsinghua.edu.cn) ; Wang, Yuguang(wangyuguang@bjmu.edu.cn)
	2025-02-28
发表期刊	NATURE COMMUNICATIONS
卷号	16 期号:1 页码:17
摘要	Noninvasive phototherapy with functional preservation is considered to be a promising cancer therapeutic method. However, the clinical application of tumor phototherapy is severely restrained by the lack of appropriate multimodal phototherapy agents exhibiting an ideal tissue penetration depth to maximize the antitumor efficiency as well as to maintain important tissue functions. Herein, an innovative near-infrared ray (NIR)-triggered photodynamic-photocatalytic-photothermal therapy (PDT-PCT-PTT) agent based on an atomically dispersed cobalt single-atom enzyme (Co-SAE) anchored on hollow N-doped carbon sphere (HNCS) has been strategically developed. Reactive oxygen species (ROS) are highly activated and amplified through both the photogenerated electrons and the photothermal conversion induced by NIR irradiation, as systematically demonstrated by the experimental and density functional theory (DFT) calculation results. Mild hyperthermia is eventually achieved through apoptosis and ferroptosis caused by ROS, significantly boosting the interaction of ROS dynamic effects and thermodynamic effects in the tumor microenvironment (TME). More importantly, Co-SAEs/HNCS not only causes multimodal damage through limited TME products but also preserves important organ functions by the induction of mild local hyperthermia. This work expands the biomedical application field of SAEs and presents an innovative all-in-one, multimodal concept for the noninvasive treatment of head and neck cancer.
资助者	National Science Foundation of China \| National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) ; National Natural Science Foundation of China ; Natural Science Foundation of Liaoning Province-Outstanding Youth Foundation
DOI	10.1038/s41467-025-57188-9
收录类别	SCI
语种	英语
资助项目	National Science Foundation of China \| National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)[22202214-A] ; National Science Foundation of China \| National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)[22171157-D] ; National Natural Science Foundation of China[2022-YQ-02-A] ; Natural Science Foundation of Liaoning Province-Outstanding Youth Foundation
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001435592900023
出版者	NATURE PORTFOLIO
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/192136
专题	中国科学院金属研究所
通讯作者	Han, Ali; Wang, Dingsheng; Wang, Yuguang
作者单位	1.Peking Univ Sch & Hosp, Peking Univ Sch & Hosp Stomatol, Dept Gen Dent 2, Beijing, Peoples R China 2.Peking Univ Sch & Hosp, Natl Ctr Stomatol, Beijing, Peoples R China 3.Peking Univ Sch & Hosp, Natl Clin Res Ctr Oral Dis, Beijing, Peoples R China 4.Peking Univ Sch & Hosp, Beijing Key Lab Digital Stomatol, Natl Engn Res Ctr Oral Biomat & Digital Med Device, Beijing, Peoples R China 5.Peking Univ Sch & Hosp, NHC Key Lab Digital Stomatol, Beijing, Peoples R China 6.Peking Univ Sch & Hosp, NMPA Key Lab Dent Mat, Beijing, Peoples R China 7.Peking Univ Sch & Hosp, Cent Lab, Beijing, Peoples R China 8.Tsinghua Univ, Dept Chem, Beijing, Peoples R China 9.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, 72 Wenhua Rd, Shenyang, Peoples R China 10.Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL USA
推荐引用方式 GB/T 7714	Dai, Hao,Han, Ali,Wang, Xijun,et al. NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy[J]. NATURE COMMUNICATIONS,2025,16(1):17.
APA	Dai, Hao,Han, Ali,Wang, Xijun,Zhu, Peng,Wang, Dingsheng,&Wang, Yuguang.(2025).NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy.NATURE COMMUNICATIONS,16(1),17.
MLA	Dai, Hao,et al."NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy".NATURE COMMUNICATIONS 16.1(2025):17.